LCoR,NRIP1蛋白在宫颈癌组织中的表达及其临床意义  

Expression and Clinical Significance of LCoR and NRIP1 Protein in Cervical Cancer

作　　者：寇国祯 刘婷婷 杨丽波 KOU Guozhen;LIU Tingting;YANG Libo(Zhumadian Traditional Chinese Medicine Hospital,Zhumadian,463000)

机构地区：[1]河南省驻马店市中医院,463000

出　　处：《实用癌症杂志》2023年第5期756-759,共4页The Practical Journal of Cancer

摘　　要：目的分析配体依赖辅助抑制因子(LCoR)、核受体相互作用蛋白1(NRIP1)在宫颈癌组织中的表达及与临床病理、预后的联系。方法选取63例宫颈癌患者,术中取患者的癌组织与癌旁正常组织,以免疫组织化学法检测LCoR、NRIP1表达。同时收集患者的年龄、淋巴结转移等临床病理资料,分析LCoR、NRIP1表达与临床病理特征之间的关系。另随访3年,以Kaplan-Meier法分析LCoR、NRIP1表达与患者预后的关系。结果癌组织LCoR、NRIP1阳性表达率高于癌旁正常组织,有统计学差异(P<0.05)。LCoR、NRIP1表达与患者年龄、病理类型、体重指数(BMI)无关,无统计学差异(P>0.05);LCoR、NRIP1表达与患者临床分期、肿瘤浸润深度、淋巴结转移、肿瘤最大径有关,有统计学差异(P<0.05)。Kaplan-Meier结果显示:LCoR、NRIP1阳性表达患者的3年生存率低于阴性表达患者,有统计学差异(P<0.05)。结论宫颈癌组织内LCoR、NRIP1呈高表达,两者与患者临床分期、肿瘤浸润深度、淋巴结转移、肿瘤最大径及预后密切相关。Objective To analyze the expression of ligand-dependent co-inhibitory factor(LCoR)and nuclear receptor interacting protein 1(NRIP1)in cervical cancer and their relationship with clinicopathology and prognosis.Methods The expression of LCoR and NRIP1 was detected by immunohistochemistry in 63 patients with cervical cancer.At the same time,the clinicopathological data of patients such as age and lymph node metastasis were collected to analyze the relationship between the expression of LCoR,NRIP1 and clinicopathological characteristics.The relationship between the expression of LCoR and NRIP1 and the prognosis of patients was analyzed by Kaplan Meier method after another 3 years of follow-up.Results The positive expression rate of LCoR and NRIP1 in cancer tissue was higher than that in normal tissue adjacent to cancer,with statistical difference(P<0.05).The expression of LCoR and NRIP1 was not related to the age,pathological type and body mass index(BMI)of patients,and there was no statistical difference(P>0.05);The expression of LCoR and NRIP1 was related to the clinical stage,depth of tumor invasion,lymph node metastasis and the maximum diameter of tumor,with statistical difference(P<0.05).Kaplan Meier results showed that the 3-year survival rate of patients with positive expression of LCoR and NRIP1 was lower than that of patients with negative expression(P<0.05).Conclusion The high expression of LCoR and NRIP1 in cervical cancer is closely related to the clinical stage,depth of tumor invasion,lymph node metastasis,maximum diameter of tumor and prognosis.

关 键 词：宫颈癌 病理类型 淋巴结 LCoR NRIP1 

分 类 号：R737.33[医药卫生—肿瘤]