局部晚期喉癌非手术与手术综合治疗的远期疗效比较  

Comparison of Long-term Efficacy Between Non-surgical and Surgical Combined Treatment for Locally Advanced Laryngeal Cancer

作　　者：闫文润[1] 杨亚萍 汤洁 YAN Wenrun;YANG Yaping;TANG Jie(The First Affiliated Hospital of Zhengzhou University,Zhengzhou,450000)

机构地区：[1]郑州大学第一附属医院,450000

出　　处：《实用癌症杂志》2023年第5期793-795,802,共4页The Practical Journal of Cancer

摘　　要：目的比较非手术与手术综合治疗在局部晚期喉癌患者中的效果。方法选取68例局部晚期喉癌患者,按随机数字表法分为2组,各34例。对照组予以非手术综合治疗(放化疗),观察组予以手术综合治疗(喉全切除术或喉部分切除术)。于治疗后随访1年,对比2组吞咽功能、生活质量与生存率。结果治疗后3个月,对照组吞咽功能优于观察组,差异有统计学意义(P<0.05)。治疗前,2组健康调查量表(SF-36)内各维度评分相比,差异无统计学意义(P>0.05);治疗后,观察组SF-36内各维度评分高于对照组,差异有统计学意义(P<0.05)。随访1年,观察组生存率为91.18%(31/34),高于对照组的70.59%(24/34),差异有统计学意义(P<0.05)。结论非手术综合治疗对局部晚期喉癌患者的吞咽功能影响较小,但手术综合治疗远期疗效更佳,可提升患者生存率,改善患者生活质量,临床需依照患者自身病情的实际情况选择个体化的治疗手段。Objective To compare the effect of non-surgical and surgical comprehensive treatment in patients with locally advanced laryngeal cancer.Methods 68 patients with locally advanced laryngeal cancer were randomly divided into 2 groups with 34 cases each.The control group received non-surgical comprehensive treatment(radiotherapy and chemotherapy),and the observation group received surgical comprehensive treatment(total laryngectomy or partial laryngectomy).The swallowing function,quality of life and survival rate of the two groups were compared after 1 year follow-up.Results Three months after treatment,the swallowing function of the control group was better than that of the observation group,the difference was statistically significant(P;Before treatment,there was no statistically significant difference in the scores of each dimension in the two groups'health survey scale(SF-36)(P>0.05);After treatment,the score of each dimension in SF-36 in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).Following up for one year,the survival rate of the observation group was 91.18%(31/34),which was higher than that of the control group(70.59%(24/34),and the difference was statistically significant(P<0.05).Conclusion Non-operative comprehensive treatment has little effect on the swallowing function of patients with locally advanced laryngeal cancer,but the long-term effect of surgical comprehensive treatment is better,which can improve the survival rate of patients and improve the quality of life of patients.In clinical practice,individualized treatment methods should be selected according to the actual conditions of patients.

关 键 词：局部晚期喉癌 手术 放化疗 生活质量 生存率 

分 类 号：R739.65[医药卫生—肿瘤]