PK-ERBT、TURBT和绿激光膀胱肿瘤整块剜除治疗非肌层浸润性膀胱癌的疗效比较  

Comparison on the Efficacy of PK-ERBT,TURBT and Green-light Laser En Bloc Enucleation of Bladder Tumors in the Treatment of Non-muscle Invasive Bladder Cancer

作　　者：焦湘 黄雪强 王文浩 JIAO Xiang;HUANG Xueqiang;WANG Wenhao(Zhumadian Central Hospital,Zhumadian,463000)

机构地区：[1]河南省驻马店市中心医院,463000

出　　处：《实用癌症杂志》2023年第5期867-870,共4页The Practical Journal of Cancer

摘　　要：目的探讨等离子膀胱瘤整块切除术(bipolar plasma kinetic en-bloc resection of bladder tumor,PK-ERBT)、传统经尿道膀胱肿瘤电切术(transurethral resection of bladder tumor,TURBT)和绿激光膀胱肿瘤整块剜除(green-light laser en bloc enucleation of bladder tumors,GLEBT)治疗非肌层浸润性膀胱癌的疗效。方法回顾性选取104例非肌层浸润性膀胱癌患者作为研究对象,按照手术方法不同分为PK-ERBT组(35例)、TURBT组(34例)和GLEBT组(35例)。比较3组患者围手术期情况(手术时间、住院天数、导尿管留置时间)、术后1年肿瘤预后标志物(P53蛋白、ki-67蛋白)表达情况、并发症发生率及复发率。结果3组围术期相关指标比较,差异有统计学意义(P<0.05)。GLEBT组与PK-ERBT组手术时间比较,无统计学意义(P>0.05);GLEBT组、PK-ERBT组手术时间、导尿管留置时间、住院天数均少于TURBT组(P<0.05);GLEBT组导尿管留置时间、住院天数少于PK-ERBT组(P<0.05)。3组术后1年肿瘤预后标志物表达情况比较,差异有统计学意义(P<0.05);PK-ERBT组、GLEBT组P53蛋白、ki-67蛋白阳性率比较,无统计学差异(P>0.05);但PK-ERBT组、GLEBT组P53蛋白、ki-67蛋白阳性率低于TURBT组(P<0.05)。3组并发症发生率比较,差异有统计学意义(P<0.05);其中PK-ERBT组、GLEBT组并发症发生率比较,差异无统计学意义(P>0.05);但PK-ERBT组、GLEBT组并发症发生率均低于TURBT组(P<0.05)。3组患者术后1年复发率比较,差异有统计学意义(P<0.05);PK-ERBT组、GLEBT组复发率均低于TURBT组(P<0.05),但PK-ERBT组、GLEBT组复发率比较,无统计学差异(P>0.05)。结论治疗非肌层浸润性膀胱癌患者,采用GLEBT相比PK-ERBT、TURBT具有更高的安全性,有望成为治疗该病的推荐手术方式。Objective To compare the efficacy of bipolar plasma kinetic en-bloc resection of bladder tumor(PK-ERBT),traditional transurethral resection of bladder tumor(TURBT)and green-light laser en bloc enucleation of bladder tumors(GLEBT)in the treatment of non-muscle invasive bladder cancer.Methods A total of 104 patients with non-muscle invasive bladder cancer were retrospectively selected,and divided into PK-ERBT group(n=35),TURBT group(n=34)and GLEBT group(n=35)according to different surgical methods.Then the perioperative indicators(operation time,length of stay,time of indwelling urinary catheter),tumor prognostic markers P53 and ki-67 expression at postoperative 1 year,complication rate and recurrence rate were compared among three groups.Results The perioperative indicators yielded statistical difference among three groups(P<0.05).The operation time,time of indwelling urinary catheter and length of stay in GLEBT group and PK-ERBT group were all shorter than those in TURBT group,with statistical difference(P<0.05).The operation time showed no statistical difference between GLEBT group and PK-ERBT group(P>0.05),while GLEBT group had decreased time to indwelling urinary catheter and shorter length of stay than those of PK-ERBT group(P<0.05).One year after operation,the expression of tumor prognostic markers demonstrated statistical difference among three groups(P<0.05).No statistical difference was found in the positive rates of P53 and ki-67 proteins between PK-ERBT group and GLEBT group(P>0.05),while the positive rates of P53 and ki-67 proteins in PK-ERBT group and GLEBT group were lower than those in TURBT group(P<0.05).The incidence rate of complications had statistical difference among three groups(P<0.05).The incidence rate of complications denoted no statistical difference between PK-ERBT group and GLEBT group(P>0.05),while the incidence of complications in PK-ERBT group and GLEBT group was lower than that in TURBT group(P<0.05).The recurrence rate at 1 year after operation in PK-ERBT group and GLEBT group was

关 键 词：PK-ERBT 绿激光膀胱肿瘤整块剜除 TURBT 非肌层浸润性膀胱癌 

分 类 号：R737.14[医药卫生—肿瘤]