含2-苯基噻唑骨架化合物的合成与抗肿瘤活性评价  

Synthesis and Antitumor Activity Evaluation of 2-phenylthiazole Skeleton Compounds

作　　者：李前 钱晶晶 马燕燕 孙慧敏 曹阳 司鑫鑫 LI Qian;QIAN Jingjing;MA Yanyan;SUN Huimin;CAO Yang;SI Xinxin(Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening,Jiangsu Ocean University,Lianyungang 222005,China)

机构地区：[1]江苏海洋大学、江苏省海洋药物筛选重点实验室,江苏连云港222005

出　　处：《合成化学》2023年第4期316-320,共5页Chinese Journal of Synthetic Chemistry

基　　金：江苏省研究生科研与实践创新计划项目(KYCX2022-31)。

摘　　要：以4-氯硫代苯甲酰胺、3-溴丙酮酸乙酯和4-三氟甲基硫代苯甲酰胺为原料,合成了10个2-苯基-1,3-噻唑骨架化合物,其结构经^(1)H NMR、^(13)C NMR和HR-MS确证。利用CCK-8法初步考察了这些化合物对人胰腺癌细胞(CFPAC-1)、人乳腺癌细胞(MDA-MB-231)和肝癌细胞(BEL-7402)的体外抗肿瘤活性,结果表明:10种化合物均具有一定的抗肿瘤活性。Using 4-chlorothiobenzamide,3-bromopyruvate ethyl ester and 4-trifluoromethyl-thiobenzamide as raw materials,ten compounds with 2-phenyl-1,3-thiazole skeleton were synthesized.Its structure was characterized by ^(1)H NMR,^(13)C NMR and confirmed by HR-MS.The antitumor activities of the synthesized compounds against human pancreatic cancer cells(CFPAC-1),human breast cancer cells(MDA-MB-231)and liver cancer cells(BEL-7402)were investigated by CCK-8 method.The results showed that all ten compounds had certain antitumor activities.

关 键 词：2-苯基-1 3-噻唑 抗肿瘤活性 有机合成 胰腺癌 乳腺癌 肝癌 

分 类 号：R914.5[医药卫生—药物化学] O621.3[医药卫生—药学]