不同人类发展指数国家肺癌发病率和死亡率分析  

Incidence and mortality of lung cancer in countries with different human development index

作　　者：朱小琼 蒋栋铭 沈佳莹 牛喆昀 胡明 曾慧娴 杨之雨 张子涵 赵存喜[1] 曹广文 ZHU Xiaoqiong;JIANG Dongming;SHEN Jiaying;NIU Zheyun;HU Ming;ZENG Huixian;YANG Zhiyu;ZHANG Zihan;ZHAO Cunxi;CAO Guangwen(School of Public Health,Anhui Medical University,Hefei,Anhui 230032,China;Medical College of Tongji University,Shanghai 430030,China;Faculty of Naval Medicine,Naval Medical University,Shanghai Key Laboratory of Medical Bioprotection,Key Laboratory of Biological Defense,Shanghai 200433,China;School of Medicine,Jinan University,Guangzhou,Guangdong 510632,China)

机构地区：[1]安徽医科大学公共卫生学院,安徽合肥230032 [2]同济大学医学院,上海430030 [3]海军军医大学海军医学系上海市医学生物防护重点实验室,生物安全防御教育部重点实验室,上海200433 [4]暨南大学基础医学院,广东广州510632

出　　处：《上海预防医学》2023年第4期305-313,共9页Shanghai Journal of Preventive Medicine

基　　金：国家自然科学基金重大研究计划集成基金项目(91529305);国家自然科学基金国际合作与交流基金项目(81520108021);国家自然科学基金面上基金项目(81673250);国家自然科学基金青年基金项目(82003538);上海市公共卫生重点学科(GWV-10.1-XK17);上海市扬帆计划(20YF1458800)。

摘　　要：【目的】比较不同人类发展指数(HDI)国家1990—2019年间肺癌年龄标准化发病率(ASIR)和年龄标准化死亡率(ASMR)的年度变化趋势及2020年的年龄变化趋势。【方法】收集1990—2019年全球疾病负担(GBD)和GLOBOCAN 2020全球肺癌发病和死亡的数据。肺癌ASIR和ASMR的平均年度变化百分比和年龄变化趋势采用Joinpoint回归模型进行分析。【结果】2020年肺癌发病率和死亡率均随着年龄和HDI等级的升高而逐渐升高。1990—2019年间全球肺癌总体ASIR和ASMR呈下降趋势,其中男性肺癌ASIR呈下降趋势,而女性肺癌ASIR则呈上升趋势。单独分析发现,1990—2019年间中国和印度的肺癌ASIR和ASMR总体呈上升趋势,而俄罗斯和美国的肺癌ASIR和ASMR总体呈下降趋势。【结论】虽然极高/高HDI国家面临着更高的肺癌发生和死亡负担,但是肺癌负担的累积主要在转型期阶段完成。因此,对正处在转型期的国家采取肺癌预防措施对全球肺癌控制至关重要。[Objective]To compare the annual and age trends of the age-standard incidence rate(ASIR)and the age-standard mortality rate(ASMR)of lung cancer in countries with different human development index(HDI)from 1990 to 2019.[Methods]The data were collected from the global burden of disease study and GLOBOCAN 2020.The average annual percentage change(AAPC)and age trends of ASIR and ASMR in lung cancer were analyzed by the Joinpoint regression model,and the comparison between the four groups was analyzed by Kruskale-Wallis analysis.[Results]In 2020,the incidence and mortality of lung cancer gradually increased with age and HDI grade.From 1990 to 2019,the global ASIR and ASMR of lung cancer decreased,and the ASIR of lung cancer among male decreased,while the ASIR of lung cancer among female increased.The results showed that ASIR of lung cancer in female residents in countries with very high HDI increased significantly from 1996 to 2011,resulting in an overall upward trend in female ASIR,while the other groups showed a downward trend.It was found that ASIR and ASMR of lung cancer in China and India were on the rise,while ASIR and ASMR of lung cancer in Russia and the United States were on the decline.[Conclusion]Although very high/high HDI countries face a higher burden of lung cancer occurrence and death,the accumulation of lung cancer burden is completed in the transitioning period.Therefore,lung cancer prevention measures in countries in transition are critical for global lung cancer control.

关 键 词：肺癌 人类发展指数 发病率 死亡率 

分 类 号：R734.2[医药卫生—肿瘤]