中药汤剂联合西药治疗儿童复发性口腔溃疡脾胃积热证临床研究  

Clinical Study on Chinese Medicine Decoction Combined with Western Medicine for Recurrent Oral Ulcer in Children with Accumulated Heat in the Spleen and Stomach Syndrome

作　　者：乐芳波 张丹萍 郑凤蕾 LE Fangbo;ZHANG Danping;ZHENG Fenglei

机构地区：[1]宁波口腔医院北仑分院综合科,浙江宁波315800

出　　处：《新中医》2023年第7期138-142,共5页New Chinese Medicine

摘　　要：目的:观察中药汤剂联合西药治疗儿童复发性口腔溃疡(ROU)脾胃积热证的临床疗效。方法:将124例ROU脾胃积热证患儿按随机数字表法分为治疗组64例与对照组60例,对照组给予常规西药治疗,治疗组在对照组基础上给予中药汤剂治疗。评估2组临床疗效、症状改善时间、复发率及治疗前后中医证候积分、免疫功能指标。结果:治疗组治疗总有效率96.88%,高于对照组85.00%(P<0.05)。治疗前,2组中医证候积分比较,差异无统计学意义(P>0.05);治疗后,2组中医证候积分低于治疗前(P<0.05),且治疗组低于对照组(P<0.05)。治疗组治疗后疼痛消失时间、溃疡愈合时间均短于对照组(P<0.05)。治疗前,2组CD3^(+)、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+)比较,差异无统计学意义(P>0.05);治疗后,2组CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)水平均升高(P<0.05),CD8^(+)水平均降低(P<0.05),且治疗组CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)水平高于对照组(P<0.05),CD8^(+)水平低于对照组(P<0.05)。治疗组复发率6.45%,低于对照组23.53%(P<0.05)。结论:中药汤剂联合西药治疗儿童ROU脾胃积热证疗效确切,可减轻患儿临床症状,促进溃疡愈合,提高患儿机体免疫力,减少复发率。Objective:To observe the clinical effect of Chinese medicine decoction combined with western medicine for recurrent oral ulcer(ROU)in children with accumulated heat in the spleen and stomach syndrome.Methods:A total of 124 cases of children with ROU with accumulated heat in the spleen and stomach syndrome were divided into the treatment group and the control group according to the random number table method,with 64 and 60 cases in each group respectively.The control group was treated with routine western medicine,and the treatment group was additionally treated with Chinese medicine decoction based on the treatment of the control group.The traditional Chinese medicine(TCM)syndrome scores and immune function indexes before and after treatment as well as the clinical effects,improvement time of symptoms and recurrence rates were evaluated in the two groups.Results:The total effective rate was 96.88%in the treatment group,higher than that of 85.00%in the control group(P<0.05).Before treatment,there was no significant difference being found in the comparison of TCM syndrome scores between the two groups(P>0.05);after treatment,TCM syndrome scores in the two groups were lower than those before treatment(P<0.05),and the score in the treatment group was lower than that in the control group(P<0.05).After treatment,the disappearance time of pain and the healing time of ulcer in the treatment group were shorter than those in the control group(P<0.05).Before treatment,there was no significant difference being found in the comparison of levels of CD3^(+),CD4^(+),CD8^(+)and CD4^(+)/CD8^(+)between the two groups(P>0.05).After treatment,the levels of CD3^(+),CD4^(+),and CD4^(+)/CD8^(+)in the two groups were increased(P<0.05),and the CD8^(+)levels were decreased(P<0.05);the levels of CD3^(+),CD4^(+),and CD4^(+)/CD8^(+)in the treatment group were higher than those in the control group(P<0.05),and the CD8^(+)level was lower than that in the control group(P<0.05).The recurrence rate was 6.45%in the treatment group,lower than that o

关 键 词：复发性口腔溃疡 儿童 脾胃积热证 中药汤剂 中医证候积分 免疫功能 

分 类 号：R781.5[医药卫生—口腔医学]