基于数据挖掘运用病机十三条探讨活血化瘀法在多发性骨髓瘤中的应用  

Exploration of the Application of Promoting Blood Circulation and Removing Blood Stasis Method in Multiple Myeloma Based on Data Mining and Thirteen Pathogenesis of Disease

作　　者：朱新宇[1] 朱垚[2] 陆明 倪海雯[1] 杨月艳[1] ZHU Xinyu;ZHU Yao;LU Ming;NI Haiwen;YANG Yueyan

机构地区：[1]南京中医药大学附属医院,江苏南京210029 [2]南京中医药大学第一临床医学院,江苏南京210023 [3]南京中医药大学针灸推拿学院养生康复学院,江苏南京210023 [4]南京医中科技有限公司中医药数据挖掘中心,江苏东南京210029

出　　处：《新中医》2023年第7期155-159,共5页New Chinese Medicine

基　　金：国家中医药管理局第四批全国中医优秀人才研修项目(国中医药办人教函[2017]24号);江苏省六大人才高峰项目(RJFW-40)。

摘　　要：目的:通过数据挖掘分析当代名医治疗多发性骨髓瘤验案,运用国医大师周仲瑛“病机十三条”之“血病多瘀”阐释活血化瘀法在多发性骨髓瘤中的应用。方法:检索建库至2022年6月20日中国期刊全文数据库(CNKI)、万方学术期刊全文数据库(Wanfang)、维普中文科技期刊数据库(VIP)收录的当代名医治疗多发性骨髓瘤医案文献,采用Medcase数据处理平台进行频数分析、关联规则分析。结果:多发性骨髓瘤高频病机依次为血瘀、气虚、肾虚;临床高频症状为神疲乏力、腰痛、肢体麻木疼痛;关联分析发现,肢体麻木疼痛与血瘀高度关联,且血瘀高关联用药为蜈蚣、全蝎等。结论:血瘀是多发性骨髓瘤的核心病机,运用“血病多瘀”理论对新药时代多发性骨髓瘤的中医辨治策略具有重要意义。Objective:Through data mining analysis of the treatment of multiple myeloma(MM)cases by contemporary famous doctors,the application of the method of promoting blood circulation and removing blood stasis in MM was explained by the"blood syndromes are mostly associated with blood stasis"in the theory of"thirteen pathogenesis of disease"by traditional Chinese medicine(TCM)master ZHOU Zhongying.Methods:The medical records of contemporary famous doctors in the treatment of MM from the establishment of the database to June 20,2022 in China National Knowledge Internet(CNKI),Wanfang Academic Journal Full-text Database(Wanfang),VIP Chinese Science and Technology Journal Database(VIP)were retrieved.The Medcase data processing platform was used for frequency analysis and association rule analysis.Results:The frequent pathogenesis of MM was blood stasis,qi deficiency and kidney deficiency.The frequent clinical symptoms were fatigue,low back pain and limb numbness and pain.Association analysis showed that limb numbness and pain were highly correlated with blood stasis,and blood stasis was associated with scolopendra and scorpio,etc.Conclusion:Blood stasis is the core pathogenesis of MM.Applying the theory of"blood syndromes are mostly associated with blood stasis"is of great significance to TCM differentiation and treatment strategy of MM in the era of new drugs.

关 键 词：多发性骨髓瘤 数据挖掘 病机十三条 活血化瘀法 

分 类 号：R733.3[医药卫生—肿瘤]