sCTLA-4、RAD51C蛋白对宫颈癌患者介入治疗术后复发的预测价值  

Predictive value of sCTLA-4 and RAD51C proteins for recurrence after interventional therapy for cervical cancer patients

作　　者：赵晓阳 李陆鹏 刘玉岩 刘建文 Zhao Xiaoyang;Li Lupeng;Liu Yuyan;Liu Jianwen(Department of Intervention Therapy,Henan Provincial People’s Hospital,People’s Hospital of Zhengzhou University,Zhengzhou 450003,China)

机构地区：[1]河南省人民医院综合介入科,郑州大学人民医院,郑州450003

出　　处：《中华内分泌外科杂志》2023年第2期239-243,共5页Chinese Journal of Endocrine Surgery

基　　金：河南省医学科技攻关计划项目(201702175)。

摘　　要：目的分析可溶性细胞毒T淋巴细胞相关抗原4(sCTLA-4)、RAD51旁系同源基因C(RAD51C)蛋白对宫颈癌患者介入治疗术后复发的预测价值。方法选取2015年5月至2019年4月河南省人民医院宫颈癌患者107例为观察组,均经介入手术治疗,统计术后复发情况,另选取同期良性宫颈疾病患者107例为对照组。比较观察组、对照组及是否复发患者sCTLA-4、RAD51C蛋白表达,采用Logistic回归分析宫颈癌患者术后复发的影响因素,构建宫颈癌患者术后复发的列线图模型并采用校准曲线验证,绘制决策曲线分析sCTLA-4、RAD51C蛋白预测宫颈癌患者术后复发的价值,并统计不同sCTLA-4、RAD51C蛋白表达患者的复发率。结果观察组sCTLA-4水平、RAD51C蛋白高表达率高于对照组(P<0.05);高危型人乳头瘤病毒阳性、脉管浸润、间质浸润≥1/2、宫旁浸润、RAD51C蛋白高表达及sCTLA-4高水平是宫颈癌患者术后复发的独立危险因素(P<0.05);高危型人乳头瘤病毒、脉管浸润、间质浸润、宫旁浸润、RAD51C蛋白及sCTLA-4水平构建宫颈癌患者术后复发的列线图预测模型,一致性指数分别为0.610(95%CI为0.511~0.702)、0.616(95%CI为0.517~0.708)、0.640(95%CI为0.541~0.730)、0.609(95%CI为0.510~0.702)、0.728(95%CI为0.633~0.809)、0.817(95%CI为0.731~0.885),且校准曲线验证显示具有较高一致性,sCTLA-4、RAD51C蛋白联合检测的净受益率大于单独检测。结论宫颈癌患者sCTLA-4、RAD51C蛋白均呈高表达,且二者同时高表达表明宫颈癌患者术后复发风险较高,临床可通过检测sCTLA-4、RAD51C蛋白表达情况筛选高复发风险患者并及早进行干预,以降低复发率。Objective To analyze the predictive value of soluble cytotoxic T lymphocyte-associated antigen 4(sCTLA-4)and RAD51 paralogous gene C(RAD51C)protein in the recurrence of cervical cancer patients after interventional therapy.Methods A total of 107 patients with cervical cancer who underwent interventional surgery in our hospital from May.2015 to Apr.2019 were selected as the research group.postoperative recurrence were recorded.Another 107 patients with benign cervical disease during the same period were selected as the control group.The protein expressions of sCTLA-4 and RAD51C were compared between the two groups and patients with or without recurrence.Logistic regression was used to analyze the influencing factors of postoperative recurrence of cervical cancer patients,and a nomogram model of postoperative recurrence of cervical cancer patients was constructed and verified by calibration curve.The postoperative recurrence rate of cervical cancer patients with different sCTLA-4 and RAD51C protein expressions was compared.Results The level of sCTLA-4 and the high expression rate of RAD51C protein in the study group were higher than those in the control group(P<0.05).High-risk human papillomavirus positive,vascular infiltration,interstitial infiltration≥1/2,paracterine infiltration,high expression of RAD51C protein and high SCTLA-4 level were independent risk factors for postoperative recurrence of cervical cancer(P<0.05).High-risk human papillomavirus,vascular invasion,interstitial invasion,parametrial invasion,RAD51C protein and sCTLA-4 levels were used to construct a nomogram prediction model for postoperative recurrence of cervical cancer patients.The consistency indices were 0.610(95%CI:0.511-0.702),0.616(95%CI:0.517-0.708),0.640(95%CI:0.541-0.730),0.609(95%CI:0.510-0.702),0.728(95%CI ranged from 0.633 to 0.809),0.817(95%CI ranged from 0.731 to 0.885),and the calibration curve validation showed high consistency.The net benefit rate of combined detection of sCTLA-4 and RAD51C proteins was greater than that of

关 键 词：宫颈癌 复发 可溶性细胞毒T淋巴细胞相关抗原4 RAD51旁系同源基因C蛋白 

分 类 号：R737.33[医药卫生—肿瘤]