长链非编码RNA-NEF在肝癌、胃癌、食管癌发生发展中的作用  

Role of long non-coding RNA-NEF in the genesis and development of hepatocellular carcinoma,gastric carcinoma,and esophageal carcinoma

作　　者：贾刚刚 李斌 卢利霞 于晓辉 JIA Ganggang;LI Bin;LU Lixia;YU Xiaohui(Department of Gastroenterology,the 940th Hospital of Joint Logistics Support Force of Chinese People’s Liberation Army,Gansu Province,Lanzhou730050,China)

机构地区：[1]中国人民解放军联勤保障部队第九四〇医院消化内科,甘肃兰州730050

出　　处：《中国医药导报》2023年第12期52-55,共4页China Medical Herald

基　　金：甘肃省青年科技基金计划项目(20JR10RA012);甘肃省非感染性肝病临床医学研究中心项目(21JR7RA017)。

摘　　要：长链非编码RNA(lncRNA)是一类长度>200个核苷酸且不编码蛋白质的RNA,通过与RNA和DNA相互作用来调节基因表达,其功能与亚细胞定位密切相关。在细胞核中,lncRNA在表观遗传和转录水平上调节基因表达;在细胞质中,其在转录后和翻译水平上调节基因表达。lncRNA作为外泌体的一种,其异常表达已被证实具有肿瘤抑制或致癌作用,并在肿瘤的增殖、凋亡、免疫逃逸等生物学过程中发挥重要作用。lncRNA-NEF是一种在肝癌中新发现的lncRNA,具有抑制肝癌上皮间质转化及转移的作用。后续研究发现,lncRNA-NEF在多种肿瘤中发挥作用,且主要表现为抑癌作用。消化系统恶性肿瘤发病率高,预后差,生存期短,本文就lncRNA-NEF的主要特征及其在肝癌、胃癌、食管癌中的作用进展进行综述,以期为发现新的肿瘤诊断标志物及预后指标提供依据,并且为其治疗提供新思路,开辟肿瘤治疗新靶点。Long non-coding RNA(lncRNA)are a class of RNAs>200 nucleotides in length that do not encode proteins.They regulate gene expression by interacting with RNA and DNA,and their functions are closely related to subcellular localization.In the nucleus,lncRNA regulate gene expression at the epigenetic and transcriptional levels,and in the cytoplasm,it regulate gene expression at the post-transcriptional and translational levels.As a kind of exosome,the abnormal expression of lncRNA has been confirmed to have tumor inhibition or carcinogenic effect,and play an important role in the biological processes of tumor proliferation,apoptosis,immune escape,and so on.LncRNA-NEF is a newly discovered lncRNA in liver cancer,which can inhibit epithelial mesenchymal transformation and metastasis of liver cancer.Follow-up studies have found that lncRNA-NEF plays a role in a variety of tumors,mainly manifested as a cancer suppressor.The incidence of malignant tumor of digestive system is high,the prognosis is poor and the survival time is short.In this paper,the main characteristics of lncRNA-NEF and the progress of its role in liver cancer,gastric cancer,and esophageal cancer were reviewed,in order to provide a basis for the discovery of new tumor diagnostic markers and prognostic indicators,and provide new ideas for its treatment and explore new targets for tumor treatment.

关 键 词：长链非编码RNA-NEF 肝癌 胃癌 食管癌 生物标志物 

分 类 号：R735[医药卫生—肿瘤]