艾司奥美拉唑联合疏肝和胃安神方对肝胃郁热型难治性胃食管反流病患者睡眠质量、胃肠激素的影响  

Effects of Esomeprazole combined with Shugan Hewei Anshen Prescription on sleep quality and gastrointestinal hormones in patients with refractory gastroesophageal reflux disease with syndrome of heat stagnation in liver and stomach

作　　者：沈鼎 叶蔚[2] SHEN Ding;YE Wei(The Third Clinical Medical College,Zhejiang Chinese Medical University,Zhejiang Province,Hangzhou310007,China;Department of Gastroenterology,Hangzhou Traditional Chinese Medicine Hospital Affiliated to the Zhejiang Chinese Medical University,Zhejiang Province,Hangzhou310007,China)

机构地区：[1]浙江中医药大学第三临床医学院,浙江杭州310007 [2]浙江中医药大学附属杭州市中医院消化内科,浙江杭州310007

出　　处：《中国医药导报》2023年第12期146-150,共5页China Medical Herald

基　　金：浙江省中医药科技计划项目(2021ZA107)。

摘　　要：目的探析艾司奥美拉唑联合疏肝和胃安神方对肝胃郁热型难治性胃食管反流病患者睡眠质量、胃肠激素的影响。方法选取2021年6月至2022年6月浙江中医药大学附属杭州市中医院行难治性胃食管反流病治疗的患者120例,按照随机数字表法将其分为中药组、西药组、联合组,每组40例。中药组给予疏肝和胃安神方;西药组给予艾司奥美拉唑;联合组给予艾司奥美拉唑联合疏肝和胃安神方治疗,三组连续治疗8周。评估中医证候积分水平;检测食团清除时间、酸反流次数、反流后吞咽诱发的蠕动波(PSPW)指数及胃动素(MTL)、胃泌素(GAS)、血管活性肠肽(VIP)水平;匹兹堡睡眠质量指数量表(PSQI)评估睡眠质量。结果治疗后,三组反酸评分、胸骨后灼痛评分、心烦易怒评分、两胁胀满评分、食团清除时间、酸反流次数、PSPW指数水平、VIP水平、PSQI评分低于治疗前,且联合组低于中药组和西药组,差异有统计学意义(P<0.05)。治疗后,三组MTL、GAS水平高于治疗前,且联合组高于中药组和西药组,差异有统计学意义(P<0.05)。结论经艾司奥美拉唑、疏肝和胃安神方联合治疗后,肝胃郁热型难治性胃食管反流病患者中医证候积分水平降低,恢复食管动力功能,改善胃肠激素水平,提升睡眠质量。Objective To investigate the effects of Esomeprazole combined with Shugan Hewei Anshen Prescription on sleep quality and gastrointestinal hormone in patients with refractory gastroesophageal reflux disease with syndrome of heat stagnation in liver and stomach.Methods A total of 120 patients receiving treatment for refractory gastroesophageal reflux disease in Hangzhou Traditional Chinese Medicine Hospital Affiliated to the Zhejiang Chinese Medical University from June 2021 to June 2022 were selected and divided into traditional Chinese medicine group,western medicine group,and combined group according to random number table method,with 40 cases in each group.The traditional Chinese medicine group was given Shugan Hewei Anshen Prescription;the western group was given Esomeprazole;the combination group was given Esomeprazole combined with Shugan Hewei Anshen Prescription,and the three groups were treated for eight weeks.The traditional Chinese medicine syndrome score level was evaluated,the scavenging time,acid reflux times,post-reflux swallow-induced peristaltic wave(PSPW)index,and the levels of motilin(MTL),gastrin(GAS),and vasoactive intestinal peptide(VIP)were detected.The Pitts-burgh sleep quality index(PSQI)was used to assess sleep quality.Results After treatment,the acid reflux score,the retrosternal burning pain score,the irritability score,the two-side swelling score,the scavenging time of food mass,the acid reflux times,the PSPW index level,the VIP level,and the PSQI score of the three groups were lower than those before treatment,and the combined group was lower than the traditional Chinese medicine group and the western medicine group,and the differences were statistically significant(P<0.05).After treatment,the MTL and GAS levels in the three groups were higher than those before treatment,and the combined group was higher than the traditional Chinese medicine group and western medicine group,and the differences were statistically significant(P<0.05).Conclusion After combined treatment with Espromepazol

关 键 词：难治性胃食管反流病 艾司奥美拉唑 疏肝和胃安神方 睡眠质量 胃肠激素 

分 类 号：R571[医药卫生—消化系统]