甲泼尼龙治疗小儿难治性癫痫的效果观察  

Effect observation of methylprednisolone in the treatment of refractory epilepsy in children

作　　者：任芳 REN Fang(Health Management Center,Binzhou People's Hospital,Binzhou Shandong Province 256600,China)

机构地区：[1]滨州市人民医院健康管理中心,山东滨州256600

出　　处：《中国城乡企业卫生》2023年第3期12-15,共4页Chinese Journal of Urban and Rural Enterprise Hygiene

摘　　要：目的 分析小儿难治性癫痫采用甲泼尼龙治疗的效果,为提升其临床干预效果提供参考。方法 选取滨州市人民医院2021年5月—2022年5月收治的难治性癫痫患儿106例为研究对象,根据双色小球法随机分为研究组和对照组各53例。对照组采用维生素B6与左乙拉西坦治疗,研究组在对照组的基础上采用甲泼尼龙进行治疗。比较两组治疗效果、治疗前后智力发育情况以及不良反应发生率。结果 研究组治疗总有效率为96.2%,高于对照组的79.2%,差异有统计学意义(χ^(2)=7.102,P<0.05)。治疗后,研究组智力评分高于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论 小儿难治性癫痫采用甲泼尼龙进行治疗的疗效更为确切,能够有效控制患儿的病情,降低癫痫发作频率,提升患儿智力水平,且未见明显不良反应,值得临床推广应用。Objective To analyze the effect of methylprednisolone in the treatment of refractory epilepsy in children,and to provide reference for improving its clinical intervention effect.Methods A total of 106 children with refractory epilepsy admitted to Binzhou People's Hospital from May 2021 to May 2022 were selected as the study subjects.They were randomly divided into the study group and the control group with 53 cases in each group according to the two-color ball method.The control group was treated with vitamin B6 and levetiracetam,while the study group was treated with methylprednisolone on the basis of the control group.The treatment effect,intelligence development before and after treatment and the incidence of adverse reactions were compared between the two groups.Results The total effective rate of treatment in the study group was 96.2%,which was higher than 79.2%in the control group,and the difference was statistically significant(χ^(2)=7.102,P<0.05).After treatment,the intelligence score of the study group was higher than that of the control group,and the difference was statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The curative effect of methylprednisolone on refractory epilepsy in children was more accurate,which could effectively control the disease condition of children,reduce the frequency of seizures,and improve the intelligence level of children,without obvious adverse reactions,and was worthy of clinical promotion and application.

关 键 词：小儿难治性癫痫 甲泼尼龙 治疗效果 

分 类 号：R742.1[医药卫生—神经病学与精神病学]