无膜亚细胞器PML核体的分子组装机制及其在癌症和感染性疾病中的研究进展  

A Systematic Review on the Mechanism of PML Nuclear Body Assembly and Its Functions in Cancers and Pathogenic Infection

作　　者：蒋雁翎 陈立 蒙国宇 JIANG Yanling;CHEN Li;MENG Guoyu(Kunming University of Science and Technology of Medicine,Kunming 650500,China;Shanghai Institute of Hematology,State Key Laboratory of Medical Genomics,National Research Center for Translational Medicine,Rui-Jin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China)

机构地区：[1]昆明理工大学医学院,昆明650500 [2]上海血液学研究所/医学基因组国家重点实验室/国家转化医学中心(上海)/上海交通大学医学院附属瑞金医院,上海200025

出　　处：《中国细胞生物学学报》2023年第3期345-355,共11页Chinese Journal of Cell Biology

摘　　要：早幼粒细胞白血病蛋白(promyelocytic leukemia protein,PML)最早在急性早幼粒细胞白血病(acute promyelocytic leukemia,APL)患者体内被发现。PML本身是一种抑癌蛋白,也是PML核体(PML nuclear bodies,PML NBs)的核心组成部分。PML NBs可以介导转录调控、蛋白修饰、细胞的衰老和凋亡等多种重要的细胞生物学过程。在APL的治疗中,针对PML的靶向治疗已经被证明是一种有效的治疗方式。已有大量的研究表明,PML蛋白和PML核体不仅在APL的发病和治疗中起着重要作用,同时也在多种癌症的发生、发展以及病毒感染中发挥着重要作用。该文回顾了PML领域近年来的研究突破,从PML的形成、相分离、翻译后修饰再到PML在多种癌症和病毒感染中的作用,以此提示PML在癌症靶向、病毒感染的治疗上或许还有更多的应用潜能。PML(promyelocytic leukemia protein)was first discovered in patients with APL(acute promyelocytic leukemia).PML itself is a tumor suppressor protein and a core component of PML NBs(PML nuclear bodies).PML NBs can mediate various important cellular biological processes such as transcriptional regulation,protein modification,cell senescence and apoptosis.In the treatment of APL,targeted therapy for PML has been shown to be an effective treatment modality.A large number of studies have shown that PML proteins and PML nucleosomes not only play an important role in the pathogenesis and treatment of APL,but also play an important role in the occurrence,development and viral infection of various cancers.This article reviews the research breakthroughs in the field of PML in recent years,from the formation of PML,phase separation,post-translational modification to the role of PML in various cancers and viral infections,suggestive of more possibilities that PML can be used in cancer targeting and viral infection therapy.

关 键 词：PML核体 组装机制 癌症 病毒感染 

分 类 号：R733.71[医药卫生—肿瘤]