线粒体介导的能量代谢对中枢神经损伤修复的作用研究进展  

Research Progress on the Effect of Mitochondria-Mediated Energy Metabolism on Repair of Central Nerve System Injury

作　　者：周美 张燕忍 魏涛 蔡淑芳 吴艳青 ZHOU Mei;ZHANG Yanren;WEI Tao;CAI Shufang;WU Yanqing(The Institute of Life Sciences,College of Life and Environmental Sciences,Wenzhou University,Wenzhou 325035,China)

机构地区：[1]温州大学,生命与环境科学学院-生命科学研究院,温州325035

出　　处：《中国细胞生物学学报》2023年第3期452-461,共10页Chinese Journal of Cell Biology

基　　金：国家自然科学基金(批准号:82272254);浙江省自然科学基金(批准号:LY22H090007);温州市基础性科研项目(批准号:Y20220060)资助的课题。

摘　　要：线粒体介导的能量代谢与中枢神经损伤修复关系密切。中枢神经损伤会导致线粒体损伤、线粒体运输变弱、局部线粒体去极化以及ATP损失,引起轴突局部能量缺乏。因此,健康线粒体数量的保证及其运输和定位的有效调节对于满足中枢神经损伤修复所需要的能量至关重要。该文综述了中枢神经损伤后,神经细胞的能量需求及线粒体动态变化,分析了线粒体功能与中枢神经损伤修复的关系,并归纳了线粒体相关的促进神经系统损伤修复策略的相关研究进展,旨在通过该综述为临床上促进中枢神经损伤修复提供新的思路。Mitochondria-mediated energy metabolism is closely related to the repair of CNS(central nerve system)injury.CNS injury will lead to mitochondrial damage,reduce the mitochondrial transport,depolarize the local mitochondria,and result in ATP loss and energy deficiency of local axons.Thus,a guarantee of number of healthy mitochondria and effective regulation of mitochondrial transport and orientation are important for satisfying the energy need of CNS repair.This paper reviews the energy requirement of nerve cells and dynamic changes of mitochondria after CNS injury,and analyzes the relationship between mitochondrial function and CNS repair.Lastly,it summarizes the related research progress of mitochondrial-related strategies for promoting the repair of CNS injury.This review aims to provide new ideas for clinically promoting CNS injury repair.

关 键 词：中枢神经损伤 线粒体 能量代谢 轴突再生 微管稳定 

分 类 号：R741[医药卫生—神经病学与精神病学]