补体C1q/肿瘤坏死因子相关蛋白6的结构与功能研究进展  

Research Advances in Structure and Function of Complement C1q/Tumor Necrosis Factor-Related Protein 6

作　　者：夏静文 李汉兵[1] 毋文静 尤忠毓 张瑾[2] XIA Jingwen;LI Hanbing;WU Wenjing;YOU Zhongyu;ZHANG Jin(College of Pharmaceutical Science,Zhejiang University of Technology,Hangzhou 310014,China;College of Biological Chemical Sciences and Engineering,Jiaxing University,Jiaxing 314000,China)

机构地区：[1]浙江工业大学药学院,杭州310014 [2]嘉兴学院生物与化学工程学院,嘉兴314000

出　　处：《中国细胞生物学学报》2023年第3期514-525,共12页Chinese Journal of Cell Biology

基　　金：国家自然科学基金(批准号:32172708);浙江省自然科学基金重点项目(批准号:LZ23C170002);浙江省农业(畜禽)新品种选育重大科技专项(批准号:2021C02068-5)资助的课题。

摘　　要：补体C1q/肿瘤坏死因子相关蛋白6(CTRP6)是与脂联素高度同源的脂肪因子,广泛表达于人体多种组织中,常以三聚体的形式发挥其生物学功能。研究表明,CTRP6在脂质代谢、肥胖症、糖尿病、炎症、肿瘤、纤维化等多种生理和病理过程中发挥重要的调控作用。此外,CTRP6在农业动物育种中也具有一定的应用前景。该文将对CTRP6的结构特征、表达调控及主要生物学功能进行全面的综述,为CTRP6的进一步研究提供参考和借鉴。CTRP6(complement C1q/tumor necrosis factor-related protein 6)is an adipokine with high homology to adiponectin.It is widely expressed in various tissues of the human body.CTRP6 normally exerts its biological function in the form of a homotrimer.Studies have shown that CTRP6 plays an important regulatory role in various physiological and pathological processes such as lipid metabolism,obesity,diabetes,inflammation,tumor and fibrosis.In addition,CTRP6 also has certain application prospects in agricultural animal breeding.This article will provide a comprehensive review of the structural characteristics,expression regulation and main biological functions of CTRP6,which will provide references for further research of CTRP6.

关 键 词：补体C1q/肿瘤坏死因子相关蛋白6 肥胖 炎症 肿瘤 纤维化 动物育种 

分 类 号：R730[医药卫生—肿瘤]