单胎与多胎早产儿视网膜病变发病及治疗情况比较分析  

Comparative analysis of the onset and treatment of retinopathy of prematurity in singleton and multiparous infants

作　　者：范弯弯 任建兵[2] 向建文[2] 史玉[2] 杨洋[2] 聂川[2] 罗先琼[3] Fan Wan-wan;Ren Jian-bin;Xiang Jian-wen(Guangzhou Medical University,Guangzhou 510180,China;不详)

机构地区：[1]广州医科大学,510180 [2]广东省妇幼保健院新生儿科 [3]广东省妇幼保健院科教科

出　　处：《中国斜视与小儿眼科杂志》2023年第1期40-41,I0010,I0011,共4页Chinese Journal of Strabismus & Pediatric Ophthalmology

基　　金：广东省中医药局中医药科研项目(20232011);广东省医学科研基金项目(B2022118)。

摘　　要：目的回顾性分析单胎与多胎ROP的发病及治疗情况。方法收集2013年1月至2015年12月广东省妇幼保健院新生儿科住院早产儿病例共4596例,使用RetCamⅡ系统进行眼底筛查,记录单胎及多胎患儿性别、胎龄、出生体重、机械通气及ROP的分期、分区、治疗等情况,使用χ^(2)检验和t检验进行统计分析。结果4596例早产儿中,诊断为ROP共239例,发病率为5.20%。单胎4096例,发生ROP 178例(4.35%),多胎500例,发生ROP 61例(12.20%),其中双胎60例,三胎1例,两组间比较差异有统计学意义(χ^(2)=55.762,P<0.001)。单胎ROP组和多胎ROP组患儿在性别、胎龄、出生体重、机械通气、急进性后极部ROP、附加病变、ROP分期、手术治疗的比较中,差异均无统计学意义(P>0.05)。然而在ROP分区的比较中,多胎组视网膜1区的病变较单胎组高[12(19.67%),11(6.18%)],差异有统计学意义(χ^(2)=9.510,P=0.009)。结论我院ROP的发病率为5.20%,多胎ROP发病率较单胎高,且多胎ROP在视网膜1区病变较单胎高。Objective To retrospectively analyze the incidence and treatment ROP in singleton and multiparous infants.Methods A total of 4596 cases of premature infants hospitalized in the neonatal department of Guangdong Maternal and Child Health Hospital from January 2013 to December 2015 were collected.Wide-field digital fundus camera(Ret-Camll)system was used for fundus screening.And the sex,gestational age,birth weight,mechanical ventilation and staging,partitioning and treatment of ROP of singleton and multiparous infants were recorded,and statistical analysis was performed using χ^(2) test and t-test.Results Among 4596 preterm infants,a total of 239 cases were diagnosed with ROP,with an incidence of 5.20%.There were 178(4.35%)cases of R0P in 4096 cases of singleton and 61(12.20%)cases of ROP in 500 cases of multiple births(60 cases of twin births and 1 case of triplet births),with statistically significant differences between the two groups(χ^(2)=55.762,P<0.001).There was no statistically significant difference between the singleton ROP group and the multiparous ROP group in terms of sex,gestational age,birth weight,mechanical ventilation,aggressive posterior ROP,plus disease,ROP staging,and surgical treatment(P>0.05).However,in the comparison of ROP partitions,the lesions in retinal zone 1 were higher in the multifetal group compared to the singleton group[12(19.67%)vs 11(6.18%)],and the difference was statistically significant(χ^(2)=9.510,P=0.009).Conclusion The prevalence of ROP in our hospital was 5.20%,the prevalence of multifetal ROP was higher than singleton,and multifetal ROP had higher lesions in retinal zone 1 than singleton ROP.

关 键 词：早产儿视网膜病 多胎 单胎 

分 类 号：R774.1[医药卫生—眼科]