Roles of NG2 Glia in Cerebral Small Vessel Disease  

作　　者：Yixi He Zhenghao Li Xiaoyu Shi Jing Ding Xin Wang 

机构地区：[1]Department of Neurology,Zhongshan Hospital,Fudan University,Shanghai 200032,China [2]State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science,Institutes of Brain Science,Fudan University,Shanghai 200032,China [3]Institute of Neuroscience,MOE Key Laboratory of Molecular Neurobiology,NMU,Shanghai 200433,China

出　　处：《Neuroscience Bulletin》2023年第3期519-530,共12页神经科学通报（英文版）

基　　金：supported by grants from the National Natural Science Foundation of China(32100798);the China Postdoctoral Science Foundation(2021M700821).

摘　　要：Cerebral small vessel disease(CSVD)is one of the most prevalent pathologic processes affecting 5%of people over 50 years of age and contributing to 45%of dementia cases.Increasing evidence has demonstrated the pathological roles of chronic hypoperfusion,impaired cerebral vascular reactivity,and leakage of the blood–brain barrier in CSVD.However,the pathogenesis of CSVD remains elusive thus far,and no radical treatment has been developed.NG2 glia,also known as oligodendrocyte precursor cells,are the fourth type of glial cell in addition to astrocytes,microglia,and oligodendrocytes in the mammalian central nervous system.Many novel functions for NG2 glia in physiological and pathological states have recently been revealed.In this review,we discuss the role of NG2 glia in CSVD and the underlying mechanisms.

关 键 词：NG2 glia Oligodendrocyte precursor cell Cerebral small vessel disease White matter injury 

分 类 号：R741[医药卫生—神经病学与精神病学]