Recent Advances in Bio-Inspired Versatile Polydopamine Platforms for “Smart” Cancer Photothermal Therapy  

作　　者：Zhi-Yuan Ma Dan-Ya Li Xin Jia Rui-Li Wang Mei-Fang Zhu 

机构地区：[1]State Key Laboratory for Modification of Chemical Fibers and Polymer Materials,College of Materials Science and Engineering,Donghua University,Shanghai 201620,China [2]Key Laboratory for Green Processing of Chemical Engineering of Xinjiang Bingtuan,School of Chemistry and Chemical Engineering,Shihezi University,Shihezi 832003,China

出　　处：《Chinese Journal of Polymer Science》2023年第5期699-712,I0007,共15页高分子科学（英文版）

基　　金：financially supported by the National Natural Science Foundation of China(No.52003047);the Science and Technology Commission of Shanghai Municipality(No.20JC1414900);the Fundamental Research Funds for the Central Universities(No.2232020D-05)。

摘　　要：Although photothermal therapy(PTT)has been developed for fighting cancers,the degradative,toxic,and metabolic nature of photothermal conversion materials(PCMs)has prevented them from being clinically implemented.Taking advantage of the surface modification strategy of mussel-inspired dopamine chemistry and its excellent photothermal conversion effect,polydopamine(Pdop)represents a versatile PTT platform,providing strategies and methods for the construction of novel Pdop-functionalized PCMs.Thanks to its adhesion and secondary reactivity,Pdop can be deposited on virtually all substrates to improve their bioavailability and biocompatibility.Pdop-based PCMs could not be only functionalized with small biomolecules via chemical bonds and/or noncovalent force but also modified with functional polymers via either the“grafting to”or“grafting from”method.This review highlights the synthetic methods,therapeutic strategies,and designs of PCMs based on Pdop in recent years to explore its scope and limitations.

关 键 词：POLYDOPAMINE Photothermal therapy Drug delivery systems Polymers Tumor theranostics 

分 类 号：R730.5[医药卫生—肿瘤] TQ317[医药卫生—临床医学]