3D-CRT与IMRT两种放疗技术在原发性肝癌患者中的应用效果  

Application Effect of 3D-CRT and IMRT Two Treatment Technology in Patients with Primary Liver Cancer

作　　者：谢剑君 陈丽民 王燕玲[1] XIE Jianjun;CHEN Limin;WANG Yanling(Zhangzhou Municipal Hospital,Zhangzhou 363000,China;不详)

机构地区：[1]漳州市医院,福建漳州363000

出　　处：《中外医学研究》2023年第12期76-80,共5页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:分析原发性肝癌患者实施三维适形放射治疗(3D-CRT)与强度调控放射治疗(IMRT)的效果。方法:回顾性分析2019年7月—2021年7月于漳州市医院收治的86例原发性肝癌患者的临床资料,根据治疗方法不同分为3D-CRT组(3D-CRT放射治疗)及IMRT组(IMRT放射治疗),各43例。比较两组剂量学参数、放疗照射时间、子野数、总子野跳数及危及器官受量;比较两组放疗后不良反应发生率。结果:IMRT组靶区平均剂量(PTVDmean)、靶区最小剂量(PTVDmin)、靶区最大剂量(PTVDmax)、靶区适形指数(CI)及靶区均匀指数(HI)均高于3D-CRT组,差异有统计学意义(P<0.05)。IMRT组的放疗照射时间长于3D-CRT组,子野数、总子野跳数少于3D-CRT组,差异有统计学意义(P<0.05)。IMRT组脊髓、左肾、右肾、胃受量低于3D-CRT组,差异有统计学意义(P<0.05)。IMRT组放疗后不良反应发生率低于3D-CRT组,差异有统计学意义(P<0.05)。结论:IMRT技术在原发性肝癌放射治疗中可有效提升靶区的照射剂量,并可降低放疗期间对危及器官的损伤程度。Objective:To analyze the efficacy of 3-dimensional conformal radiotherapy(3D-CRT)and intensity modulated radiotherapy(IMRT)in patients with primary liver cancer.Method:A retrospective analysis was conducted of 86 patients with primary liver cancer admitted to Zhangzhou Municipal Hospital from July 2019 to July 2021,according to different treatment methods,they were divided into 3D-CRT group(3D-CRT radiotherapy)and IMRT group(IMRT radiotherapy),43 cases in each group.The dosimetric parameters,radiation exposure time,sub field number,total sub fields jump number and organ endangered dose were compared between the two groups.The incidence of adverse reactions after radiotherapy was compared between the two groups.Result:The planning target volume mean dose(PTVDmean),planning target volume minimum dose(PTVDmin),planning target volume maximum dose(PTVDmax),target area conformal index(CI),and target area homogeneity index(HI)in the IMRT group were higher than those in the 3D-CRT group,the differences were statistically significant(P<0.05).The irradiation time of IMRT group was longer than that of 3D-CRT group,and the number of sub fields and total sub field jumps were lower than those of 3D-CRT group,the differences were statistically significant(P<0.05).The dose of spinal cord,left kidney,right kidney and stomach in IMRT group were lower than those in 3D-CRT group,the differences were statistically significant(P<0.05).The incidence of adverse reactions after radiotherapy in the IMRT group was lower than that in the 3D-CRT group,the difference was statistically significant(P<0.05).Conclusion:IMRT technology can effectively increase the radiation dose at the target area and reduce the degree of damage to organs during radiotherapy for primary liver cancer.

关 键 词：三维适形放射治疗 强度调控放射治疗 原发性肝癌 放疗照射时间 总子野跳数 

分 类 号：R735.7[医药卫生—肿瘤]