Inhibition of ALDH2 by disulfiram leads to synthetic lethality via ROS strikes twice in ARID1A-deficient cholangiocarcinoma  

作　　者：Tingming Liang Lin Jia Rui Duan Lulu Shen Dekang Ren Yujie Ren Yuyang Dou Li Guo 

机构地区：[1]Jiangsu Key Laboratory for Molecular and Medical Biotechnology,School of Life Science,Nanjing Normal University,Nanjing,Jiangsu210023,China [2]Department of Bioinformatics,Smart Health Big Data Analysis and Location Services Engineering Lab of Jiangsu Province,School of Geographic and Biologic Information,Nanjing University of Posts and Telecommunications,Nanjing,Jiangsu 210023,China

出　　处：《Genes & Diseases》2023年第1期69-71,共3页基因与疾病（英文）

基　　金：This work was supported by the National Natural Science Foundation of China(Nos.62171236 and 61771251);the National Natural Science Foundation of Jiangsu,China(No.BK20171443);sponsored by NUPTSF,China(No.NY220041);the Qinglan Project in Jiangsu Province;the Priority Academic Program Development of Jiangsu Higher Education Institution(PAPD),China.

摘　　要：Synthetic lethality describes an interaction whereby the co-occurrence of two mutations leads to cell death but one mutation alone does not,which can be exploited for cancer therapeutics.1 Due to lacking effective nonsurgical treatment and early clinical diagnosis markers,patients have high mortality and low overall survival rates in cholangiocarcinoma(CCA).

关 键 词：diagnosis mortality ALONE 

分 类 号：R735.8[医药卫生—肿瘤]