折叠式人工玻璃体球囊的临床应用及研究进展  

Clinical application and research progress of foldable capsular vitreous body

作　　者：马胜男(综述) 赵素贞 郝淼 周玮琰(审校) MA Shengnan;ZHAO Suzhen;HAO Miao;ZHOU Weiyan(Provincial Hospital Affiliated to Shandong First Medical University,Jinan 250021,China)

机构地区：[1]山东第一医科大学附属省立医院,济南250021

出　　处：《眼科学报》2023年第4期338-343,共6页Eye Science

基　　金：山东省医药卫生科技发展计划(2019WS499);济南市临床医学科技创新计划(201907095)。

摘　　要：玻璃体替代物是玻璃体切割术后的必需品,用于填充玻璃体腔,恢复玻璃体的支撑视网膜、屈光和细胞屏障等功能。严重眼外伤及复杂视网膜脱离引起的视网膜/脉络膜脱离,如选用传统的玻璃体替代物(如硅油)填充,部分患者会出现硅油依赖眼或眼球萎缩,眼球难以保全。折叠式人工玻璃体球囊(foldable capsular vitreous body,FCVB)是我国独立研发的挽救眼球的人工玻璃体,属于国际首创,可以精细模拟自然玻璃体的结构,恢复玻璃体的部分功能。目前临床研究证实FCVB不仅可以有效避免硅油的并发症,还可以维持后房空间,缓慢恢复睫状体的功能,从而治疗硅油依赖眼,阻止眼球进一步萎缩。该文综述了FCVB的研究背景、结构特点、临床应用和拓展研究进展。Vitreous substitutes are necessary after vitrectomy to fill the vitreous cavity and restore the vitreous to support retinal,refractive,and cellular barrier functions.Severe ocular trauma-induced retinal/choroidal detachment filled with traditional vitreous substitutes(e.g.,silicone oil)can lead to silicone oil-dependent eyes and ocular atrophy in some patients,making it difficult to preserve the eye.Foldable capsular vitreous body(FCVB)is an artificial vitreous body independently developed in China to save the eye,which is the first of its kind in the world and can finely simulate the structure of natural vitreous body and restore some of the functions of vitreous body.It has been clinically proven that it can not only effectively avoid the complications of silicone oil,but also maintain the posterior chamber space and slowly restore the function of the ciliary body,thus treating silicone oil-dependent eyes and preventing further atrophy of the eye.This article reviews the research background,structural features,clinical applications and extended studies of FCVB.

关 键 词：折叠式人工玻璃体球囊 玻璃体 玻璃体替代物 眼外伤 

分 类 号：R779.6[医药卫生—眼科]