无抽搐电休克联合阿立哌唑对精神分裂症患者疗效及血清BDNF、S100B水平的影响  

Efficacy of modified electric convulsive therapy combined with aripiprazole on patients with schizophrenia and its influence on levels of BDNF and S100B

作　　者：李世兴 LI Shi-xing(Department of Psychiatry,Geo Encephalopathy Hospital,Siping 136000,China)

机构地区：[1]四平吉奥脑病医院精神科,136000

出　　处：《中国现代药物应用》2023年第7期124-127,共4页Chinese Journal of Modern Drug Application

摘　　要：目的探讨无抽搐电休克联合阿立哌唑对精神分裂症患者疗效及血清脑源性神经营养因子(BDNF)、星形胶质源性蛋白(S100B)水平的影响。方法196例精神分裂症患者,采用随机数字表法分为对照组及观察组,每组98例。对照组采用阿立哌唑治疗,观察组采用无抽搐电休克联合阿立哌唑治疗。比较两组临床疗效,治疗前后的精神病高危症状评定量表(SOPS)及韦氏记忆量表(WMS-RC)评分,治疗前后的血清BDNF、S100B水平,不良反应发生率。结果观察组治疗总有效率为92.86%,高于对照组的81.63%,差异具有统计学意义(P<0.05)。治疗后,两组SOPS评分较治疗前降低、WMS-RC评分较治疗前升高,且观察组SOPS评分(40.10±10.47)分低于对照组的(56.23±12.52)分、WMS-RC评分(85.54±17.14)分高于对照组的(72.33±14.66)分,差异具有统计学意义(P<0.05)。治疗后,两组血清BDNF水平较治疗前升高、S100B水平较治疗前降低,且观察组BDNF水平(20.13±3.40)ng/ml高于对照组的(18.47±3.24)ng/ml,S100B水平(0.98±0.21)ng/ml低于对照组的(1.22±0.24)ng/ml,差异具有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论无抽搐电休克联合阿立哌唑治疗精神分裂症效果显著,可改善患者认知功能,调节血清BDNF、S100B水平,且安全性良好,值得进一步推广应用。Objective To discuss the efficacy of modified electric convulsive therapy combined with aripiprazole on patients with schizophrenia and its influence on levels of serum brain-derived neurotrophic factor(BDNF)and astrocyte-derived protein(S100B).Methods A total of 196 patients with schizophrenia were divided into control group and observation group according to the random numerical table,with 98 cases in each group.The control group was treated with aripiprazole,and the observation group was treated with modified electric convulsive therapy and aripiprazole.Both groups were compared in terms of clinical efficacy,Scale of Psychosis-Risk Symptoms(SOPS)and Wechsler Memory Scale-Revised in Chinese(WMS-RC)before and after treatment,the levels of serum BDNF and S100B before and after treatment,and the incidence of adverse reactions.Results The total effective rate of treatment in the observation group was 92.86%,which was higher than 81.63%in the control group,and the difference was statistically significant(P<0.05).After treatment,the SOPS score in both groups decreased and the WMS-RC score increased compared with that before treatment in this group;the SOPS score was(40.10±10.47)points in the observation group,which was lower than(56.23±12.52)points in the control group;the WMS-RC score was(85.54±17.14)points in the observation group,which was higher than(72.33±14.66)points in the control group;the differences were statistically significant(P<0.05).After treatment,serum BDNF levels in both groups increased and S100B levels decreased compared with those before treatment in this group;the BDNF level(20.13±3.40)ng/ml in the observation group was higher than(18.47±3.24)ng/ml in the control group;the S100B level(0.98±0.21)ng/ml in the observation group was lower than(1.22±0.24)ng/ml in the control group;the differences were statistically significant(P<0.05).The difference was not statistically significant when comparing the incidence of adverse reactions between the two groups(P>0.05).Conclusion Modified electric c

关 键 词：精神分裂症 无抽搐电休克 阿立哌唑 血清脑源性神经营养因子 星形胶质源性蛋白 

分 类 号：R749.3[医药卫生—神经病学与精神病学]