住院精神分裂症患者伴发非酒精性脂肪肝相关因素的性别差异  

Gender differences in factors associated with the development of nonalcoholic fatty liver disease in hospitalized schizophrenic patients

作　　者：孟美玲 韩艳丽 张袁杰 班春霞[1] 陈翔春[1] 于伟霞 王湖 汪崇泽[4] 高存友 Meng Meiling;Han Yanli;Zhang Yuanjie;Ban Chunxia;Chen Xiangchun;Yu Weixia;Wang Hu;Wang Chongze;Gao Cunyou(WardⅣof Psychology Department,Mental Health Center of Jiading District,Shanghai 201823,China;Department of Medical Administration,Mental Health Center of Jiading District,Shanghai 201823,China;WardⅡof Psychology Department,Mental Health Center of Jiading District,Shanghai 201823,China;Psychology Department,Mental Health Center,School of Medicine,Shanghai Jiao Tong University,Shanghai 201108,China)

机构地区：[1]上海市嘉定区精神卫生中心精神科四病区,201823 [2]上海市嘉定区精神卫生中心医务部,201823 [3]上海市嘉定区精神卫生中心精神科二病区,201823 [4]上海交通大学医学院附属精神卫生中心精神科,201108

出　　处：《神经疾病与精神卫生》2023年第3期172-179,共8页Journal of Neuroscience and Mental Health

基　　金：上海市精神卫生中心院级课题(2020-YJ15)。

摘　　要：目的探讨住院精神分裂症患者伴非酒精性脂肪肝(NAFLD)的患病率以及影响因素的性别差异。方法选取2020年7月1日至2021年6月30日在上海市嘉定区精神卫生中心住院的316例精神分裂症患者为研究对象。采用多因素Logistic回归分析住院精神分裂症患者以及不同性别患者伴NAFLD的影响因素。结果住院精神分裂症患者的NAFLD患病率为41.1%(130/316),其中男性患者为42.1%(82/195),女性患者为39.7%(48/121)。多因素Logistic回归分析显示,女性(OR=2.345,95%CI=1.159~4.743)、体重指数高(OR=1.445,95%CI=1.296~1.610)、甘油三酯高(OR=2.715,95%CI=1.709~4.315)、丙氨酸氨基转移酶(ALT)高(OR=1.019,95%CI=1.002~1.037)、住院时长长(OR=1.099,95%CI=1.040~1.162)、合并糖尿病(OR=2.879,95%CI=1.225~6.768)是住院精神分裂症患者伴NAFLD的危险因素(P<0.05)。多因素Logistic回归分析显示,男性住院精神分裂症患者体重指数高(OR=1.524,95%CI=1.324~1.753)、甘油三酯高(OR=2.841,95%CI=1.652~4.887)是伴NAFLD的危险因素(P<0.05);女性患者体重指数高(OR=1.370,95%CI=1.186~1.582)、血糖高(OR=1.982,95%CI=1.218~3.225)是伴NAFLD的危险因素(P<0.05),发病年龄大(OR=0.939,95%CI=0.889~0.991)是女性患者伴NAFLD的保护因素(P<0.05)。结论住院精神分裂症患者的NAFLD患病率较高,与性别、体重指数、甘油三酯、ALT、住院时长、是否患糖尿病相关,且影响因素存在性别差异,在临床中应重视防治住院精神分裂症患者发生NAFLD。Objective To explore the gender differences in the prevalence and influencing factors of nonalcoholic fatty liver disease(NAFLD)in hospitalized schizophrenia patients.Methods A total of 316 schizophrenic inpatients admitted to Shanghai Jiading District Mental Health Center from 1 July 2020 to 30 June 2021 were recruited.Multivariate Logistic regression analysis were applied to analyze schizophrenia inpatients and influencing factors of NAFLD in patients with different genders.Results The prevalence of NAFLD in hospitalized schizophrenics was 41.1%(130/316),with a prevalence of 42.1%(82/195)in male patients and 39.7%(48/121)in female patients.Multivariate Logistic regression analysis showed that the influencing factors of NAFLD in hospitalized schizophrenia patients were female(OR=2.345,95%CI=1.159-4.743),high body mass index(BMI)(OR=1.445,95%CI=1.296-1.610),high triglyceride(TG)(OR=2.715,95%CI=1.709-4.315),high alanine aminotransferase(ALT)(OR=1.019,95%CI=1.002-1.037),long hospitalized time(OR=1.099,95%CI=1.040-1.162),diabetes(OR=2.879,95%CI=1.225-6.768)(P<0.05).Multivariate Logistic regression analysis showed that high BMI(OR=1.524,95%CI=1.324-1.753)and high TG(OR=2.841,95%CI=1.652-4.887)were the risk factors of NAFLD in male hospitalized schizophrenia patients(P<0.05);high BMI(OR=1.370,95%CI=1.186-1.582)and high blood glucose(OR=1.982,95%CI=1.218-3.225)were the risk factors of NAFLD in female hospitalized schizophrenia patients(P<0.05);elder age of onset(OR=0.939,95%CI=0.889-0.991)was the protective factor of NAFLD in female hospitalized schizophrenia patients(P<0.05).Conclusions The prevalence of NAFLD in hospitalized patients with schizophrenia is high,and significantly associated with gender,BMI,TG,ALT,length of hospitalization time and diabetes,and there are gender differences in influencing factors.Therefore,attention should be paid to the prevention and treatment of NAFLD in hospitalized schizophrenia patients in clinical practice.

关 键 词：精神分裂症 非酒精性脂肪肝 患病率 性别 

分 类 号：R749.3[医药卫生—神经病学与精神病学] R575.5[医药卫生—临床医学]