贝飞达、益君康、思连康及金双歧对洛哌丁胺导致便秘的影响  

Effects of Bifido,Yijunkang,Siliankang,and Golden Bifid on loperamide induced constipation

作　　者：余婧婷 程小英 詹扬 李颖萌 刘文君 Jing-Ting Yu;Xiao-Ying Cheng;Yang Zhan;Ying-Meng Li;Wen-Jun Liu(Jiangzhong Pharmaceutical Co.,Ltd,Nanchang 330096,Jiangxi Province,China)

机构地区：[1]江中药业股份有限公司,江西省南昌市330096

出　　处：《世界华人消化杂志》2023年第9期361-368,共8页World Chinese Journal of Digestology

摘　　要：背景便秘是常见的胃肠道疾病,也是结直肠癌的危险因素.益生菌是临床使用最广泛的用于治疗便秘的微生态制剂,常见肠道微生态药品有贝飞达、益君康、思连康、金双歧等,它们的菌株组成成分不同,对便秘的治疗效果可能也不同.目的探究并比较这4种微生态制剂对便秘模型大鼠的作用,并评估这些益生菌对便秘相关指标的影响.方法将大鼠随机分为对照组(Control)、模型组(Model)、贝飞达组(Bifido)、益君康组(Yijunkang)、思连康组(Siliankang)和金双歧(Golden bifid)组,每组10只.测定各组大鼠的体重、粪便数量、形态、含水率及肠道推进率;HE染色观察各组大鼠肠道的病理学改变;阿尔新蓝染色分析肠道粘蛋白的表达水平.结果各组大鼠的体重及粪便含水率没有显著变化;相对于模型组,贝飞达组的粪便数量(P<0.01)、肠道推进率(P<0.05)、肠粘膜厚度(P<0.01)、粘蛋白表达水平(P<0.01)显著增加;益君康组肠道推进率(P<0.05)和粘蛋白表达(P<0.001)显著增加;思连康组的肠道推进率及粘蛋白水平增加(P<0.05);金双歧组观察粘蛋白表达增加(P<0.01).结论这4种微生态制剂均被发现可以在不同程度上改善便秘,其中贝飞达的改善效果最佳.本研究结果表明,贝飞达可以显著增加便秘大鼠的粪便数量及肠道转运率,增加粘蛋白的表达水平,促进肠道粘液分泌,改善大鼠胃肠蠕动,缓解便秘相关症状.BACKGROUND Constipation is a common gastrointestinal disorder and a risk factor for colorectal cancer.Probiotics are the most widely used microecological agents for the treatment of constipation in clinical practice.Common intestinal microecological drugs include Bifido,Yijunkang,Siliankang,Golden Bifid,etc.They have different composition and may have different therapeutic effects on constipation.AIM To compare the effects of the four microecological agents in a rat model of constipation and to assess the effects of these probiotics on constipation-related indicators.METHODS Rats were randomly divided into six groups:Control group,model group,Bifido group,Yijunkang group,Siliankang group,and Golden Bifid group,with 10 rats in each group.The body weight,fecal quantity,shape,and water content,and intestinal transit rate of rats in each group were measured.Hematoxylin-eosin staining was performed to observe the pathological changes in the intestine of rats in each group.The expression level of intestinal mucin was analyzed by Alcian blue staining.RESULTS There were no significant changes in body weight and fecal water content of rats in each group.Compared to the model group,the quantity of feces(P<0.01),intestinal transit rate(P<0.05),intestinal mucosal thickness(P<0.01),and mucin expression level(P<0.01)were significantly increased in the Bifido group.Intestinal transit rate(P<0.05)and mucin expression(P<0.001)were significantly increased in the Yijunkang group.Increased intestinal transit rate and mucin level were observed in the Siliankang group(P<0.05),and increased mucin expression was observed in the Golden Bifid group(P<0.01).CONCLUSION The four microecological preparations improve constipation to varying degrees,of which Bifido has the best effect.Bifido can significantly increase the quantity of feces and intestinal transit rate of constipation rats,increase the expression level of mucin,promote the secretion of intestinal mucus,improve gastrointestinal peristalsis,and relieve constipation related symptoms

关 键 词：益生菌 便秘 洛哌丁胺 肠道菌群 贝飞达 益君康 思连康 金双歧 

分 类 号：R574.62[医药卫生—消化系统]