儿童B族链球菌脑膜炎研究进展  

Progress of group B streptococcus meningitis in children

作　　者：李文洁(综述) 胡越(审校)[1] Li Wenjie;Hu Yue(Department of Neurology,Children′s Hospital of Chongqing Medical University,National Clinical Research Center for Child Health and Disorders(Chongqing),Ministry of Education Key Laboratory of Child Development and Disorders,Chongqing Key Laboratory of Pediatrics,Chongqing 400014,China)

机构地区：[1]重庆医科大学附属儿童医院神经内科、国家儿童健康与疾病临床医学研究中心、儿童发育疾病研究教育部重点实验室、儿科学重庆市重点实验室,400014

出　　处：《国际儿科学杂志》2023年第3期195-199,共5页International Journal of Pediatrics

摘　　要：B族链球菌(group B streptococcus,GBS),又称无乳链球菌,是一种可定植在健康人体中的革兰阳性条件致病球菌。GBS为3月龄以内婴儿细菌性脑膜炎的常见病原菌。GBS血清型Ⅲ及序列型ST 17最常见,毒力强,且血清型Ⅲ和ST 17之间存在明显相关性,对红霉素高度耐药。青霉素或氨苄西林为国内一线用药。GBS脑膜炎患儿预后不良风险高。新生儿存在GBS侵袭的特定高危因素时可给予产时抗生素预防,可降低GBS早发型发病率,但并没有显著降低早发型病死率及晚发型发病率。Group B streptococcus(GBS),also known as streptococcus agalactis,is a Gram-positive conditionally causative coccus that can colonize healthy humans.GBS is a common pathogen of bacterial meningitis in infants under 3 months of age.GBS serotypeⅢand sequence type 17(ST 17)are the most common and virulent,and there is a significant correlation between serotypeⅢand ST 17,and erythromycin resistance is high.Penicillin or ampicillin is the first-line drug in China.Children with GBS meningitis are at high risk of poor prognosis.Intrapartum antibiotic prophylaxis(IAP)may be given in the presence of specific risk factors for GBS invasion in newborns.IAP reduced the incidence of early-onset GBS,but did not significantly reduce early-onset mortality and late-onset morbidity.

关 键 词：儿童 B族链球菌 细菌性脑膜炎 流行病学 临床特征 

分 类 号：R742.9[医药卫生—神经病学与精神病学]