免疫调控在正畸牙移动中相关作用的研究进展  

Research progress in immunomodulation in orthodontic tooth movement

作　　者：张柯佳 张瀚文 严斌[1] Zhang Kejia;Zhang Hanwen;Yan Bin(Department of Orthodontics,Affiliated Hospital of Stomatology,Nanjing Medical University&Jiangsu Province Key Laboratory of Oral Diseases&Jiangsu Province Engineering Research Center of Stomatological Translational Medicine,Nanjing 210029,China;Department of Pathophysiology,School of Basic Medical Sciences,Nanjing Medical University,Nanjing 211166,China)

机构地区：[1]南京医科大学附属口腔医院正畸科、江苏省口腔疾病研究重点实验室、江苏省口腔转化医学工程研究中心,南京210029 [2]南京医科大学基础医学院病理生理学系,南京211166

出　　处：《中华口腔医学杂志》2023年第4期380-385,共6页Chinese Journal of Stomatology

基　　金：国家自然科学基金(82071143,82270361);江苏省重点研发计划(BE2022795);江苏省卫生健康委科研项目(ZDA2020003);江苏高校优势学科建设工程项目(2018-87)。

摘　　要：在正畸牙移动过程中,破骨细胞和成骨细胞等细胞的功能行使受免疫系统多种细胞或分子的影响,因此越来越多的学者开始探索免疫系统在正畸骨改建中的作用。本文基于不同免疫细胞或细胞因子的生物学作用,简要阐述免疫调控在正畸牙移动中的相关作用,并展望其未来趋势,以期对口腔正畸牙移动中的生物学机制有更全面的认识和了解。In the process of orthodontic tooth movement,the secretion of cytokines by immune cells or cell-cell interaction affects the regulation of osteoclast and osteoblast differentiation.Increasingly,studies have focused on the role in the immune system in orthodontic bone remodeling.Based on the biological role of different immune cells or cytokines,this article briefly presents the research progress of immunomodulation in orthodontic tooth movement and future perspective,hopefully providing a deeper and more comprehensive understanding of the biological mechanism in orthodontic tooth movement.

关 键 词：牙正畸牵引 牙移动 免疫 免疫 细胞 免疫因子类 骨重建 骨免疫学 

分 类 号：R783.5[医药卫生—口腔医学]