结直肠癌中DRP1、p53及Ki67的表达及临床意义  

Expression and clinical significance of DRP1,p53 and Ki67 proteins in colorectal cancer

作　　者：丁剑锋[1] 刘颖[2] 靳钦[2] 王伟[2] 周正友 DING Jianfeng;LIU Ying;JIN Qin;WANG Wei;Zhou Zhengyou(Trauma Center,the Affiliated Hospital of Nantong University,Nantong,Jiangsu 226001,China;Department of Pathology,the Affiliated Hospital of Nantong University,Nantong,Jiangsu 226001,China;Department of Pathology,Nanzheng People’s Hospital,Hanzhong,Shaanxi 723100,China)

机构地区：[1]南通大学附属医院创伤中心,江苏南通226001 [2]南通大学附属医院病理科,江苏南通226001 [3]南郑区人民医院病理科,陕西汉中723100

出　　处：《重庆医学》2023年第9期1363-1367,共5页Chongqing medicine

基　　金：2021年度江苏省南通市级基础科学研究项目(JC2021029)。

摘　　要：目的观察结直肠癌动力相关蛋白1(DRP1)、p53及Ki67的表达情况,并探讨其临床意义。方法收集2018年1月至2020年11月于南通大学附属医院行结直肠癌根治术并经病理诊断为结直肠腺癌的141例患者癌组织及对应癌旁组织,应用免疫组织化学法检测DRP1、p53及Ki67的表达情况,并分析其与临床病理特征的相关性。结果结直肠癌组织中DRP1、p53、Ki67阳性表达率均明显高于癌旁组织(P<0.05)。不同肿瘤浸润深度(N分期)、淋巴结转移(T分期)、TNM分期及肿瘤分化程度的患者结直肠癌组织DRP1和Ki67阳性表达率比较,差异均有统计学意义(P<0.05)。更高的肿瘤T分期、N分期、TNM分期患者结直肠癌组织中p53阳性表达率更高,差异均有统计学意义(P<0.05)。结直肠癌组织中DRP1与p53、Ki67表达水平呈正相关(r=0.348、0.471,P<0.001),p53与Ki67表达水平也呈正相关(r=0.353,P<0.001)。结论DRP1在结直肠癌组织中表达升高,且与结直肠癌恶性生物学行为相关,DRP1可能作为评估结直肠癌恶性程度和进展的有效指标。Objective To observe the expression of dynamin-related protein 1(DRP1),p53 and Ki67 in colorectal cancer,and to explore their clinical significance.Methods From January 2018 to November 2020,the cancer tissues and corresponding adjacent tissues of 141 colorectal cancer patients who underwent radical resection of colon cancer and were diagnosed as colorectal cancer by pathology were collected.The expressions of DRP1,p53 and Ki67 were detected by immunohistochemistry,and their correlation with clinicopathological characteristics was analyzed.Results The positive expression rates of DRP1,p53 and Ki67 in colorectal cancer tissues were significantly higher than those in adjacent tissues(P<0.05).The positive expression rate of DRP1 and Ki67 in colorectal cancer tissues was correlated with tumor invasion depth(N stage),lymph node metastasis(T stage),tumor node metastasis(TNM)stage,and tumor differentiation degree,with statistical significance(P<0.05).The positive expression rate of p53 in colorectal cancer tissues of patients with higher T stage,N stage and TNM stage was higher,and the differences were statistically significant(P<0.05).The expression of DRP1 in colorectal cancer tissues was positively correlated with the expression of p53 and Ki67(r=0.348,0.471,P<0.001),the expression of p53 was also positively correlated with the expression of Ki67(r=0.353,P<0.001).Conclusion The expression of DRP1 is increased in colorectal cancer tissues,and it is related to the malignant biological behavior of colorectal cancer.DRP1 can be used as an effective indicator for evaluating the malignant degree and progression of colorectal cancer.

关 键 词：结直肠癌 病理 动力相关蛋白1 P53 KI67 

分 类 号：R735.34[医药卫生—肿瘤]