CSPG4在胃肠间质瘤中的表达及其与临床参数及肿瘤免疫细胞的关系  

Expression of CSPG4 in gastrointestinal stromal tumor and its relationship with clinical parameters and tumor immune cells

作　　者：张向莲[1] 王兴芬[1] 王志强 梁锐 ZHANG Xianglian;WANG Xingfen;WANG Zhiqiang;LIANG Rui(Department of Pathology,Second Hospital of Tianjin Medical University,Tianjin 300211,China;Department of Anorectal Surgery,Second Hospital of Tianjin Medical University,Tianjin 300211,China)

机构地区：[1]天津医科大学第二医院病理科,天津300211 [2]天津医科大学第二医院肛肠外科,天津300211

出　　处：《现代肿瘤医学》2023年第9期1683-1686,共4页Journal of Modern Oncology

基　　金：天津市科技计划项目(编号:21JCYBJC01730)。

摘　　要：目的:通过检测硫酸软骨素蛋白聚糖4(chondroitin sulfate proteoglycan 4,CSPG4)在胃肠间质瘤(gastrointestinal stromal tumor, GIST)中的表达情况,探讨其与临床病理参数和免疫细胞的相关性。方法:运用免疫组化EnVision二步法检测162例GIST中CSPG4蛋白的表达情况,分析其与年龄、性别、发生部位及NIH危险度分级的相关性,并探讨GIST中CSPG4蛋白的表达与肿瘤浸润淋巴细胞(tumor-infiltrating lymphocytes, TILs)CD4^(+)、CD8^(+)、CD20^(+)、CD56^(+)及CD68^(+)细胞计数的关系。结果:CSPG4蛋白在GIST中的表达与发生部位及NIH危险度分级相关(P<0.05),与年龄及性别差异无统计学意义(P>0.05)。CSPG4蛋白在GIST中的表达与CD8^(+)、CD56^(+)及CD68^(+)细胞计数相关(P<0.05),而与CD4^(+)及CD20^(+)细胞计数差异无统计学意义(P>0.05)。结论:CSPG4蛋白表达水平在一定程度上可预测GIST的生物学行为,CSPG4蛋白可能通过调节肿瘤免疫微环境参与GIST的发生和发展。Objective:To investigate the expression of chondroitin sulfate proteoglycan 4(CSPG4)in gastrointestinal stromal tumor(GIST),and its correlation with clinicopathological parameters and immune cells.Methods:The expression of CSPG4 protein in 162 GIST cases was measured by immunohistochemistry with EnVision,and the correlation with age,gender,site of occurrence and NIH risk grade was analyzed.The relationship between the expression of CSPG4 protein in GIST and the CD4^(+),CD8^(+),CD20^(+),CD56^(+)and CD68^(+)cell counts in tumor-infiltrating lymphocytes(TILs)was also investigated.Results:The expression of CSPG4 protein in GIST was correlated with the site of occurrence and NIH risk grade(P<0.05),and wasn't correlated with age and gender(P>0.05).The expression of CSPG4 protein in GIST was correlated with CD8^(+),CD56^(+)and CD68^(+)cell counts(P<0.05),and wasn't correlated with CD4^(+)and CD20^(+)cells(P>0.05).Conclusion:The expression level of CSPG4 protein can partly predict the biological behavior of GIST,and CSPG4 protein may participate in the development of GIST by regulating the tumor immune microenvironment.

关 键 词：硫酸软骨素蛋白聚糖4 胃肠间质瘤 肿瘤浸润淋巴细胞 肿瘤微环境 

分 类 号：R735[医药卫生—肿瘤]