超声引导下口腔颌面-颈部脉管畸形聚桂醇硬化介入治疗的临床应用  

Clinical application of ultrasonic guided sclerotherapy with poly cinnamol in the treatment of vascular malformations in oral maxillofacial head and neck region

作　　者：赵亮[1] 蓝立勤 韦荣文[2] 潘志崇[1] ZHAO Liang;LAN Li-qin;WEI Rong-wen(Department of Oral and Maxillofacial Surger,Guangxi Hechi People's Hospital,Hechi Guangxi 547000,China;Department of Ultrasound,Guangxi Hechi People's Hospital,Hechi Guangxi 547000,China)

机构地区：[1]广西河池市人民医院口腔颌面外科,广西河池547000 [2]广西河池市人民医院超声科,广西河池547000

出　　处：《临床和实验医学杂志》2023年第6期654-658,共5页Journal of Clinical and Experimental Medicine

基　　金：广西壮族自治区卫生厅(编号:Z2014347);河池市科技计划项目(编号:河科AB200704)。

摘　　要：目的探讨超声引导下口腔颌面-头颈部脉管畸形聚桂醇硬化介入治疗的临床应用效果。方法前瞻性选取2018年5月至2022年10月广西河池市人民医院收治的60例口腔颌面-颈部脉管畸形患者作为研究对象,按照随机数字表法分为观察组与对照组,每组30例。所有患者均应用硬化剂进行治疗,其中对照组患者应用平阳霉素作为硬化剂,观察组患者应用聚桂醇作为硬化剂。对比两组患者临床治疗效果、介入治疗次数、硬化剂使用量与术后疼痛程度、外观满意度,治疗前后炎症因子[降钙素原(PCT)、C反应蛋白(CRP)]与肿瘤大小以及生活质量。结果观察组治疗总有效率为96.67%,高于对照组(76.67%),差异有统计学意义(P<0.05)。观察组术后疼痛评分为(2.13±0.25)分,明显低于对照组[(2.75±0.36)分],平均每次硬化剂使用量、外观满意度为(14.36±4.68)mL、90.00%,明显高于对照组[(7.94±1.25)mL、66.67%],差异均有统计学意义(P<0.05),两组治疗次数比较,差异无统计学意义(P>0.05)。治疗后1 d,两组患者CRP、PCT水平、肿瘤大小比较,差异均无统计学意义(P>0.05),治疗后3 d,两组患者CRP、PCT水平、肿瘤大小均降低,且观察组为(73.15±9.36)μg/mL、(1.01±0.19)ng/mL、(0.62±0.16)cm,明显低于对照组[(97.65±8.24)μg/mL、(2.28±0.53)ng/mL、(1.26±0.35)cm],差异均有统计学意义(P<0.05)。两组患者远期不良反应发生率比较,差异无统计学意义(P>0.05);观察组术后近期不良反应发生率为6.67%,明显低于对照组(13.33%),差异有统计学意义(P<0.05)。结论对口腔颌面-颈部脉管畸形患者采取超声引导下聚桂醇硬化治疗能够提升治疗效果,比平阳霉素更能够减少介入治疗次数、硬化剂使用量,降低术后疼痛程度,且应用聚桂醇硬化治疗的患者对外观满意度更高,而且能够降低患者术后近期炎症水平,缩小肿瘤大小,进一步提升患者生活质量。Objective To investigate the clinical effect of ultrasonic guided sclerotherapy with poly cinnamol for vascular malformations in oral maxillofacial head and neck region.Methods Sixty patients with oral and maxillofacial-cervical chorioretinal malformations admitted to Guangxi Hechi People's Hospital from May 2018 to October 2022 were prospectively selected as study subjects,and they were divided into observation group and matched group according to the random number table method,with 30 cases in each group.All patients were treated with sclerotherapy,in which patients in the matched group applied pinyamycin as a sclerosing agent and patients in the observation group applied polyglaucine as a sclerosing agent.The clinical treatment effects,the number of interventions,the amount of sclerosing agent used with the degree of postoperative pain,satisfaction with appearance,inflammatory factors[procalcitonin(PCT),C-reactive protein(CRP)]and tumor size and quality of life before and after treatment in both groups were compared.Results The total effective rate of treatment in the observation group was 96.67%,which was higher than that in the control group(76.67%),and the difference was statistically significant(P<0.05).The postoperative pain scores of the observation group were(2.13±0.25)points,which were significantly lower than those of the control group[(2.75±0.36)points],the average amount of sclerosing agent used each time,and the appearance satisfaction were(14.36±4.68)mL,90.00%,which were significantly higher than those of the control group[(7.94±1.25)mL,66.67%],the differences were statistically significant(P<0.05),and there was no difference in the number of treatments between the two groups(P>0.05).There was no statistically significant difference in the levels of CRP,PCT and tumor size between the two groups at 1 day after treatment(P>0.05);at 3 day after treatment,the levels of CRP,PCT related inflammatory factors and tumor size in the two groups decreased,and the observation group were(73.15±9.36)μg/mL,

关 键 词：超声引导 口腔颌面 头颈部 脉管畸形 聚桂醇 

分 类 号：R782.2[医药卫生—口腔医学]