Weakened humoral immune responses of inactivated SARS-CoV-2 vaccines in patients with solid tumors  

作　　者：Zhiwei Chen Peng Zhu Zuojin Liu Bin Zhu Guobing Yin Jia Ming Rui Song Qingbo Pan Tong Li Xingwei Jiang Bing Wang Shuaibin Liu Hongxing Cai Jingjie Wang Yuling Han Zijing Lin Yang Hong Min Chen Mingli Peng Lina Hu Dachuan Cai Hong Ren 

机构地区：[1]Department of Infectious Diseases,Key Laboratory of Molecular Biology for Infectious Diseases(Ministry of Education),Institute for Viral Hepatitis,the Second Affiliated Hospital of Chongqing Medical University,Chongqing 400010,P.R.China [2]Department of Gastrointestinal Surgery,the Second Affiliated Hospital of Chongqing Medical University,Chongqing 400010,P.R.China [3]Department of Hepatobiliary Surgery,the Second Affiliated Hospital of Chongqing Medical University,Chongqing 400010,P.R.China [4]Department of Thoracic and Cardiovascular Surgery,the Second Affiliated Hospital of Chongqing Medical University,Chongqing 400010,P.R.China [5]Department of Breast and Thyroid Surgery,the Second Affiliated Hospital of Chongqing Medical University,Chongqing 400010,P.R.China [6]Department of Gynaecology and Obstetrics,Reproductive Medicine Center,the Second Affiliated Hospital of Chongqing Medical University,Chongqing 400010,P.R.China

出　　处：《Cancer Communications》2023年第2期280-284,共5页癌症通讯（英文）

基　　金：the Ethics Committee of the Second Affiliated Hospital of Chongqing Medical University and conformed with the ethical guidelines of the Declaration of Helsinki(Ratification No.133/2022);Written informed consentwas obtained fromall the participants.This study has been registered at ClinicalTrials.gov(NCT05043246).

摘　　要：Dear Editor Coronavirus disease 19(COVID-19),caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),remains a pandemic.Cancer patients have a higher risk of poor outcomes for SARS-CoV-2 infection than the general population[1].Vaccines were shown to effectively prevent SARS-CoV-2 infection,severe disease progression,and mortality.Inactivated SARS-CoV-2 vaccines(BBIBPCorV and CoronaVac)have been approved and widely used in China,with the former shown to be more effective than the latter[2].Hence,there is an urgent need to investigate the safety and humoral immune responses of inactivated vaccines in cancer patients.

关 键 词：PATIENTS vaccines HUMORAL 

分 类 号：R373[医药卫生—病原生物学] R186[医药卫生—基础医学]