3D anatomy of autonomic innervations in immune organs of a non-human primate and the human  

作　　者：Ying Cao Tingting Liu Xin Zhou Wei Fu Jiali Li Jing Yang 

机构地区：[1]State Key Laboratory of Membrane Biology,School of Life Sciences,Center for Life Sciences,Peking University,Beijing 100871,China [2]Academy for Advanced Interdisciplinary Studies,Peking University,Beijing 100871,China [3]Department of General Surgery,Peking University Third Hospital,Beijing 100191,China [4]IDG/McGovern Institute for Brain Research,Peking University,Beijing 100871,China [5]Kunming Institute of Zoology,Chinese Academy of Sciences,Kunming,Yunnan 650223,China [6]Shenzhen Bay Laboratory,Institute of Molecular Physiology,Shenzhen,Guangdong 518055,China [7]Chinese Institute for Brain Research,Beijing 102206,China

出　　处：《Fundamental Research》2023年第2期249-256,共8页自然科学基础研究（英文版）

基　　金：funded by the National Natural Science Foundation of China (To J.Y.,31771111,31970974,32061143007,32125017 and 32150008).

摘　　要：Direct neural inputs to immune organs have been observed for decades,with their functions in neuroimmune regulation being increasingly appreciated.However,the current knowledge of such neural structures,particularly those in primate immune organs,remains incomplete.In this study,we comprehensively assessed the 3D anatomy of autonomic(i.e.,sympathetic and parasympathetic)innervations in the immune organs of the rhesus macaque monkey and the human for the first time.Aided with the advanced technique of whole-tissue immunolabeling and lightsheet fluorescence imaging,we revealed the densely organized sympathetic architecture in the parenchyma of the adult monkey and human spleens.On the other hand,only sparse,if any,sympathetic inputs were observed inside the lymph nodes,Peyer's patches,or thymus.In contrast,there were minimal parasympathetic innervations in the parenchyma of these examined immune organs.Together,this work has documented the unique patterns of autonomic innervations in different immune organs of a non-human primate and the human,serving as an essential reference for future research on neuroimmune regulation in the field.

关 键 词：3D neural anatomy Autonomic innervations Immune organs Rhesus macaque HUMAN 

分 类 号：Q95[生物学—动物学]