Comparison of anterior segment parameters of the eye between type 2 diabetic with and without diabetic retinopathy and non-diabetic  

作　　者：Foroozan Narooie-Noori Amir Asharlous Ali Mirzajani Ebrahim Jafarzadehpur Mehdi Behnia Mehdi Khabazkhoob 

机构地区：[1]Rehabilitation Research Center,Department of Optometry,School of Rehabilitation Sciences,Iran University of Medical Sciences,Tehran 1968653111,Iran [2]Noor Research Center for Ophthalmic Epidemiology,Noor Eye Hospital,Tehran 1968653111,Iran [3]Department of Basic Sciences,School of Nursing and Midwifery,Shahid Beheshti University of Medical Sciences,Tehran 1968653111,Iran

出　　处：《International Journal of Ophthalmology(English edition)》2023年第4期571-578,共8页国际眼科杂志（英文版）

基　　金：Supported by Iran University of Medical Sciences。

摘　　要：AIM:To compare anterior segment parameters between two groups of type 2 diabetic with and without diabetic retinopathy(DR)and non-diabetic elderly subjects based on hemoglobin A1c(Hb A1c)levels and status of DR.METHODS:This study was conducted on 997 residents aged 60y or over in Tehran,Iran.Diabetic group had Hb A1c level≥6.4%with no other systemic problems.The non-diabetic participants had normal eye findings and no systemic diseases.K1,K2,mean K,Q-value,anterior,central,posterior,and total corneal densitometric findings,anterior chamber volume(ACV),anterior chamber depth(ACD),corneal volume(CV),and pachymetry were measured by Pentacam AXL.RESULTS:A total of 678 non-diabetic(39%male)and 319 diabetic(35%male)subjects with mean age of 66.31±5.23 and 67.22±4.96y were examined,respectively.No statistically significant difference was found in anterior segment parameters between non-diabetic and diabetic groups(all P>0.05).However,middle,posterior,and total corneal densitometric values were statistically different between two groups af ter controlling the ef fects of confounders(P=0.014,0.007,and 0.042,respectively).Corneal densitometric values in all layers,ACD,and ACV were different between diabetic subjects with and without DR(all P<0.05).In the diabetic group,only corneal densitometric values had a negative relationship with fasting blood sugar(P<0.001).ACD and ACV had a negative correlation with Hb A1c levels(all P<0.05,r=-0.129 and-0.146,respectively).However,the relationships were not observed after controlling the confounders(P=0.938,0.466,respectively).CONCLUSION:Considering the higher densitometric values of the cornea and lower ACD and ACV in diabetic subjects with DR,it is suggested that the examiners should perform comprehensive retinal examinations when faced with such conditions.

关 键 词：anterior segment DIABETES HYPERGLYCEMIA RETINOPATHY CORNEA 

分 类 号：R587.2[医药卫生—内分泌] R774.1[医药卫生—内科学]