Receded near point of convergence as a predictor of mild cognitive impairment in the general geriatric population:results from a population-based study  

作　　者：Asgar Doostdar Hassan Hashemi Payam Nabovati Amir Asharlous Mehdi Khabazkhoob 

机构地区：[1]Rehabilitation Research Center,Department of Optometry,School of Rehabilitation Sciences,Iran University of Medical Sciences,Tehran 1449614535,Iran [2]Noor Research Center for Ophthalmic Epidemiology,Noor Eye Hospital,Tehran 19839-63113,Iran [3]Department of Basic Sciences,School of Nursing and Midwifery,Shahid Beheshti University of Medical Sciences,Tehran 1968653111,Iran

出　　处：《International Journal of Ophthalmology(English edition)》2023年第4期623-629,共7页国际眼科杂志（英文版）

基　　金：Supported by Iran University of Medical Sciences (IUMS)。

摘　　要：AIM:To investigate the relationship between near point of convergence(NPC)and mild cognitive impairment(MCI)in the general elderly population.METHODS:The present report is a part of the Tehran Geriatric Eye Study(TGES):a population-based crosssectional study conducted on individuals 60 years of age and above living in Tehran,Iran using the multi-stage stratified random cluster sampling method.Cognitive status was assessed using the Persian version of the Mini-Mental State Examination(MMSE).All study participants underwent complete ocular examination including measurement of uncorrected and best-corrected visual acuity,objective and subjective refraction,cover testing,NPC measurement,and slit-lamp biomicroscopy.RESULTS:The data of 1190 individuals were analyzed for this report.The mean age of the participants analyzed was 66.82±5.42(60-92y)and 728(61.2%)of them were female.Patients with MCI had a significantly more receded NPC compared to subjects with normal cognitive status(10.89±3.58 vs 7.76±2.71 cm,P<0.001).In the multivariable logistic regression model and in the presence of confounding variables,a receded NPC was statistically significantly associated with an increased risk of MCI(odds ratio:1.334,95%confidence interval:1.263 to 1.410,P<0.001).According to receiver operating characteristic(ROC)analysis,a cut point NPC>8.5 cm(area under the curve:0.764,P<0.001)could predict the presence of MCI with a sensitivity and specificity of 70.9%and 69.5%,respectively.CONCLUSION:A receded NPC can be clinically proposed as a predictor of MCI in older adults.It is recommended that elderly with a receded NPC>8.50 cm undergo detailed cognitive screening for a definite diagnosis of MCI.In this case,the necessary interventions can be carried out to slow down MCI progression to dementia.

关 键 词：near point of convergence mild cognitive impairment GERIATRICS population-based study 

分 类 号：R749.1[医药卫生—神经病学与精神病学]