Current trends in acute pancreatitis:Diagnostic and therapeutic challenges  

作　　者：Enver Zerem Admir Kurtcehajic Suad Kunosić Dina Zerem Malkočević Omar Zerem 

机构地区：[1]Department of Medical Sciences,The Academy of Sciences and Arts of Bosnia and Herzegovina,Sarajevo 71000,Bosnia and Herzegovina [2]Department of Gastroenterology and Hepatology,Plava Medical Group,Tuzla 75000,Bosnia and Herzegovina [3]Department of Physics,Faculty of Natural Sciences and Mathematics,University of Tuzla,Tuzla 75000,Bosnia and Herzegovina [4]Department of Internal Medicine,Cantonal Hospital“Safet Mujić”Mostar,Mostar 88000,Bosnia and Herzegovina

出　　处：《World Journal of Gastroenterology》2023年第18期2747-2763,共17页世界胃肠病学杂志（英文版）

摘　　要：Acute pancreatitis(AP)is an inflammatory disease of the pancreas,which can progress to severe AP,with a high risk of death.It is one of the most complicated and clinically challenging of all disorders affecting the abdomen.The main causes of AP are gallstone migration and alcohol abuse.Other causes are uncommon,controversial and insufficiently explained.The disease is primarily characterized by inappropriate activation of trypsinogen,infiltration of inflammatory cells,and destruction of secretory cells.According to the revised Atlanta classification,severity of the disease is categorized into three levels:Mild,moderately severe and severe,depending upon organ failure and local as well as systemic complications.Various methods have been used for predicting the severity of AP and its outcome,such as clinical evaluation,imaging evaluation and testing of various biochemical markers.However,AP is a very complex disease and despite the fact that there are of several clinical,biochemical and imaging criteria for assessment of severity of AP,it is not an easy task to predict its subsequent course.Therefore,there are existing controversies regarding diagnostic and therapeutic modalities,their effectiveness and complications in the treatment of AP.The main reason being the fact,that the pathophysiologic mechanisms of AP have not been fully elucidated and need to be studied further.In this editorial article,we discuss the efficacy of the existing diagnostic and therapeutic modalities,complications and treatment failure in the management of AP.

关 键 词：PANCREATITIS Etiology and pathogenesis Diagnostic criteria NUTRITION ANTIBIOTICS Management of complications 

分 类 号：R576[医药卫生—消化系统]