Wingless/It/β-catenin signaling in liver metastasis from colorectal cancer:A focus on biological mechanisms and therapeutic opportunities  

作　　者：Federico Selvaggi Teresa Catalano Rossano Lattanzio Roberto Cotellese Gitana Maria Aceto 

机构地区：[1]Department of Surgical,ASL2 Lanciano-Vasto-Chieti,Ospedale Clinicizzato SS Annunziata of Chieti,Chieti 66100,Italy [2]Department of Clinical and Experimental Medicine,University of Messina,Messina 98125,Italy [3]Department of Innovative Technologies in Medicine&Dentistry,University“G.d’Annunzio”Chieti-Pescara,Chieti 66100,Italy [4]Department of Medical,Oral and Biotechnological Sciences,University“G.d’Annunzio”Chieti-Pescara,Chieti 66100,Italy [5]Villa Serena Foundation for Research,Villa Serena-Del Dott.L.Petruzzi,CittàSant’Angelo 65013,Pescara,Italy [6]Department of Medical,Oral and Biotechnological Sciences,“G.d’Annunzio”University of Chieti-Pescara,Chieti 66100,Italy

出　　处：《World Journal of Gastroenterology》2023年第18期2764-2783,共20页世界胃肠病学杂志（英文版）

摘　　要：The liver is the most common site of metastases in patients with colorectal cancer.Colorectal liver metastases(CRLMs)are the result of molecular mechanisms that involve different cells of the liver microenvironment.The aberrant activation of Wingless/It(Wnt)/β-catenin signals downstream of Wnt ligands initially drives the oncogenic transformation of the colon epithelium,but also the progression of metastatization through the epithelial-mesenchymal transition/mesenchymalepithelial transition interactions.In liver microenvironment,metastatic cells can also survive and adapt through dormancy,which makes them less susceptible to pro-apoptotic signals and therapies.Treatment of CRLMs is challenging due to its variability and heterogeneity.Advances in surgery and oncology have been made in the last decade and a pivotal role for Wnt/β-catenin pathway has been recognized in chemoresistance.At the state of art,there is a lack of clear understanding of why and how this occurs and thus where exactly the opportunities for developing anti-CRLMs therapies may lie.In this review,current knowledge on the involvement of Wnt signaling in the development of CRLMs was considered.In addition,an overview of useful biomarkers with a revision of surgical and non-surgical therapies currently accepted in the clinical practice for colorectal liver metastasis patients were provided.

关 键 词：Wingless/It/β-catenin signaling Colorectal cancer Epithelial-mesenchymal transition/mesenchymal-epithelial transition Liver metastasis Markers Surgical and non-surgical therapies 

分 类 号：R735.34[医药卫生—肿瘤]