Quick photofabrication of functional nanospheres from de novo designed peptides for NIR fluorescence and MR imaging  

作　　者：Jingyi Zhao Chen Li Xue-Wang Gao Ke Feng Hao Liu Sijie He Wenhua Zhao Shumin Yang Jianqun Shao Ling Ye Bin Chen Nan Xie Chen-Ho Tung Li-Zhu Wu 

机构地区：[1]School of Pharmaceutical Sciences,Capital Medical University,Beijing 100069,China [2]Key Laboratory of Photochemical Conversion and Optoelectronic Materials,Technical Institute of Physics and Chemistry,Chinese Academy of Sciences,Beijing 100190,China

出　　处：《Nano Research》2023年第3期4029-4038,共10页纳米研究（英文版）

基　　金：supported by Beijing Natural Science Foundation(No.2222051);the National Natural Science Foundation of China(No.81973442).

摘　　要：Combining the noncovalent and covalent interactions,a series of peptide amphiphiles were designed de novo and synthesized to architect functional assemblies by means of photochemistry.The strand of peptide sequence was structurally capped with photoactive tyrosine-tyrosine(YY)motifs at both termini,and the spacing was filled by alternating of hydrophilic D(L-aspartate)and hydrophobic X(ε-aminocaproic acid)structure.Upon visible-light irradiation,these de novo designed peptides underwent rapid photocrosslinking within merely 10 min.Interestingly,the modulation of alternating D-X pairs in occupying spacer would adjust molecular amphiphilicity,regulate charge distribution,and control particle size and loading capacity of peptide nanospheres(PNS)in aqueous media.With entirely peptide-based matrix,this PNS system could host cationic indicators of fluorescent rhodamine and magnetic GdIII for exemplar near infrared(NIR)fluorescence and magnetic resonance(MR)imaging,which paves a pathway to biomaterial and biomedical applications using de novo designed peptides.

关 键 词：synthetic peptide PHOTOCROSSLINKING de novo design encapsulable nanosphere imaging nanoprobe DITYROSINE 

分 类 号：TN21[电子电信—物理电子学]