Near-infrared light-driven multifunctional metal ion(Cu^(2+))-loaded polydopamine nanomotors for therapeutic angiogenesis in critical limb ischemia  

作　　者：Liang Gui Juju Huang Yi Xing Yongjun Li Junjie Zou Yingwei Zhu Xiao Liang Xiwei Zhang Qiang Xu Xin Du 

机构地区：[1]Department of Vascular Surgery,The First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,China [2]Department of Gastroenterology,The Affiliated Wuxi No.2 People’s Hospital of Nanjing Medical University,Wuxi 214002,China [3]Beijing Key Laboratory for Bioengineering and Sensing Technology,Department of Chemistry&Biological Engineering,University of Science&Technology,Beijing 100083,China [4]Department of Vascular Surgery,Beijing Hospital,National Center of Gerontology,Institute of Geriatric Medicine,Chinese Academy of Medical Science and Peking Union Medical College,Beijing 100730,China [5]Department of Anesthesiology,The Affiliated Wuxi No.2 People’s Hospital of Nanjing Medical University,Wuxi 214002,China [6]Department of Intervention,Wujin Hospital Affiliated to Jiangsu University,Wujin Clinical College of Xuzhou Medical University,Changzhou 213002,China [7]Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy,Xuzhou Medical University,Xuzhou 221004,China

出　　处：《Nano Research》2023年第4期5108-5120,共13页纳米研究（英文版）

基　　金：supported by the National Natural Science Foundation of China(No.82170515);Open Research Fund of Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy(No.XZSYSKF2021038);Jiangsu Funding Program for Excellent Postdoctoral Talent,and Changzhou Municipal Health Commission Science and Technology Project(No.ZD202126).

摘　　要：Most of the current nanomedicine-based treatments for critical limb ischemia(CLI)only aim at promoting angiogenesis,ignoring the negative influence on the therapeutic effects caused by the complex pathological micro-environment of ischemic tissue.Herein,near-infrared(NIR)light-driven metal ion(Cu^(2+))-loaded polydopamine(PDA)nanomotors(JMPN@Cu^(2+))is designed and prepared.Due to the good antioxidant and anti-inflammatory activities of PDA,JMPN@Cu^(2+)exhibits excellent biocompatibility and significantly improves the ischemic micro-environment.Additionally,based on superior photothermal conversion effect and jellyfish-like structure,the nanomotors are quickly propelled under NIR laser with low energy intensity to acquire the ability of movement and facilitate intracellular uptake of JMPN@Cu^(2+)by endothelial cells,resulting in the enhanced pro-angiogenic effect of Cu^(2+).Moreover,in vivo experimental findings show that JMPN@Cu^(2+)combined with NIR irradiation can successfully accelerate blood flow recovery and improve muscle repair.Taking these results together,this kind of nanomotor can promote angiogenesis along with ischemic micro-environment amelioration,holding great potential applications for the treatment of limb ischemia.

关 键 词：NANOMOTORS POLYDOPAMINE near-infrared(NIR)light COPPER therapeutic angiogenesis 

分 类 号：TB383[一般工业技术—材料科学与工程]