De novo engineering of nanoformulation from traditional Chinese medicine mixtures for psoriasis  

作　　者：Yang Li Dan Zhang Tianzi Shi Yulin Yu Yinmei Tian Qi Xie Jingyu Shi Li Kong Conglian Yang Zhiping Zhang 

机构地区：[1]Tongji School of Pharmacy,Huazhong University of Science and Technology,Wuhan 430030,China [2]Department of Pharmacy,Wuhan No.1 Hospital,Tongji Medical School,Huazhong University of Science and Technology,Wuhan 430022,China [3]Department of Pharmacy,Liyuan Hospital,Tongji Medical School,Huazhong University of Science and Technology,Wuhan 430077,China [4]Hubei Engineering Research Centre for Novel Drug Delivery System,Wuhan 430030,China

出　　处：《Nano Research》2023年第4期5279-5291,共13页纳米研究（英文版）

基　　金：supported by the National Natural Science Foundation of China(Nos.82173760 and 82104098);the Program for HUST Academic Frontier Youth Team(No.2018QYTD13);Scientific Research Project of Wuhan Municipal Health Commission(No.WX20Q16).

摘　　要：Nanotechnology has been widely applied in the development of traditional Chinese medicine(TCM).Interestingly,we found that nanostructures intrinsically existed in 12 clinically applied TCM mixtures(TCMMs).However,the role of these nanostructures in TCMMs and their potential value in improving the development of TCMMs remain unknown.Taking Qingxuechushi mixture as an example,we demonstrated that nanoparticles could be the most efficient part through the pharmacodynamics study on psoriasis model.By imitating the physical properties and chemical composition of isolated nanoparticles in Qingxuechushi mixture,a novel nanoformulation with definite components and good therapeutic effect was developed,which not only mimicked the prescription composition rules in the original TCMMs but also possessed the advantage of nanotechnology.This novel nanoformulation could notably alleviate the psoriasis-like manifestations and reduce the levels of pro-inflammatory factors in serum in the psoriasis mouse model.This work organically integrates the advantages of TCMMs and nanotechnology,which may provide a new approach and inspiration for the development of TCM.

关 键 词：traditional Chinese medicine NANOTECHNOLOGY PSORIASIS NANOSTRUCTURES glycyrrhiza protein 

分 类 号：R758.63[医药卫生—皮肤病学与性病学]