Manganese-doped mesoporous polydopamine nanoagent for T1-T2 magnetic resonance imaging and tumor therapy  

作　　者：Xiuqi Hou Xi Yang Yanwen Xu Jiayin Lin Fang Zhang Xiaohui Duan Sitong Liu Jie Liu Jun Shen Xintao Shuai Zhong Cao 

机构地区：[1]School of Biomedical Engineering,Sun Yat-sen University,Guangzhou 510006,China [2]Department of Radiology,Sun Yat-sen Memorial Hospital,Sun Yat-sen University,Guangzhou 510120,China [3]Translational Medicine Institute,Shenzhen Second People’s Hospital,the First Affiliated Hospital of Shenzhen University Health Science Center,Shenzhen 518035,China [4]Nanomedicine Research Center,The Third Affiliated Hospital of Sun Yat-sen University,Guangzhou 510630,China

出　　处：《Nano Research》2023年第2期2991-3003,共13页纳米研究（英文版）

基　　金：supported by the National Natural Science Foundation of China(Nos.51933011 and 31971296);the Key Areas Research and Development Program of Guangzhou(No.202007020006);Guangdong Basic and Applied Basic Research Foundation(No.2020A1515010523);Guangzhou Science and Technology Bureau(No.202102010181);Guangdong Provincial Key Laboratory of Sensing Technology and Biomedical Instrument(Sun Yat-sen University,No.2020B1212060077);approved by the Institutional Animal Care and Use Committee at Sun Yat-sen University(SYSU-IACUC-2021-000225).

摘　　要：Theranostic nanodrugs combining magnetic resonance imaging(MRI)and cancer therapy have attracted extensive interest in cancer diagnosis and treatment.Herein,a manganese(Mn)-doped mesoporous polydopamine(Mn-MPDA)nanodrug incorporating the nitric oxide(NO)prodrug BNN6 and immune agonist R848 was developed.The nanodrug responded to the H^(+)and glutathione being enriched in tumor microenvironment to release R848 and Mn^(2+).The abundant Mn^(2+)produced through a Fenton-like reaction enabled a highly sensitive T1-T2 dual-mode MRI for monitoring the tumor accumulation process of the nanodrug,based on which an MRI-guided laser irradiation was achieved to trigger the NO gas therapy.Meanwhile,R848 induced the re-polarization of tumor-promoting M2-like macrophage to a tumoricidal M1 phenotype.Consequently,a potent synergistic antitumor effect was realized in mice bearing subcutaneous 4T1 breast cancer,which manifested the great promise of this multifunctional nanoplatform in cancer treatment.

关 键 词：mesoporous polydopamine magnetic resonance imaging T1-T2 dual-mode NO gas therapy immunotherapy 

分 类 号：R730.5[医药卫生—肿瘤]