Terbium-doped zinc oxide constructed dual-light-responsive nitric oxide-releasing platform for bacterial keratitis treatment  

作　　者：Yue Sun Wei Zhang Menghui Wang Huijie Liu Qun Li Jiazhe Luo Mengzhen Zhao Shichen Liu Xiaolei Wang 

机构地区：[1]School of Chemistry and Chemical Engineering,Nanchang University,Nanchang 330088,China [2]The National Engineering Research Center for Bioengineering Drugs and the Technologies,Institute of Translational Medicine,Nanchang University,Nanchang 330088,China

出　　处：《Nano Research》2023年第1期849-857,共9页纳米研究（英文版）

基　　金：This work was funded by the National Natural Science Foundation of China(No.31860263);the Key Youth Project of Jiangxi Province(No.20202ACB216002).

摘　　要：Bacterial keratitis(BK)is a principal factor contributing to corneal ulcers and ocular complications,and has become a significant killer of global vision health.Traditional antibiotic therapy has unsatisfactory therapeutic effect due to short residence time and low utilization rate of drug,and the long-term abuse of antibiotics can easily incur the prevalence of drug-resistant bacteria.Furthermore,antibiotics are not effective in addressing the excessive inflammatory response caused by infection.Here,we developed a terbium-doped zinc oxide constructed dual-light-responsive nitric oxide(NO)-releasing nanoparticle(ZT@P@B)and modified it on the surface of contact lenses(CL-ZT@P@B)to boost its bioavailability.In vitro and in vivo experimental results verified that ZT@P@B could simultaneously respond to green light(GL)and 808 nm near-infrared(NIR)without obvious damage to the eyes,releasing reactive oxygen species(ROS)and NO,which could effectively kill bacteria(including drug-resistant strains)and reduce inflammatory response.The platform provides a promising strategy for the prevention and treatment of BK.

关 键 词：zinc oxide nitric oxide dual-light-responsive bacterial keratitis contact lenses 

分 类 号：R772.21[医药卫生—眼科]