炎性因子在童年期创伤与抑郁严重程度之间的中介作用  

Mediating effect of inflammatory factors between childhood trauma and depression severity

作　　者：陈欢[1,2] 王冉 黄凡凡[3] 刘不凡 卢文婷 赵天宇[3] 郭世杰 杨丽 任若佳[3] 高媛媛 于鲁璐[3] 安翠霞[3] 王学义[3] CHEN Huan;WANG Ran;HUANG Fanfan;LIU Bufan;LU Wenting;ZHAO Tianyu;GUO Shijie;YANG Li;REN Ruojia;GAO Yuanyuan;YU Lulu;AN Cuixia;WANG Xueyi(Mental health center of Hebei Medical University,Shijiazhuang 050031,China)

机构地区：[1]河北医科大学第一医院 [2]重庆市精神卫生中心,重庆401147 [3]河北医科大学精神卫生中心,河北省精神心理疾病临床医学研究中心,河北省精神卫生研究所,河北医科大学第一医院精神卫生科,河北省脑科学与精神心理疾病重点实验室,河北省脑老化与认知神经科学实验室,河北省精神心理健康评估与干预技术创新中心

出　　处：《中国神经精神疾病杂志》2023年第3期146-150,共5页Chinese Journal of Nervous and Mental Diseases

基　　金：河北省省级科技计划资助(编号:21377711D);河北省省级科技计划资助(编号:199776245D);河北省省级科技计划资助(编号:LS201903);河北医科大学十四五临床医学创新研究团队(编号:2022LCTD-A1);河北省引进外国智力项目(编号:YZ202204)。

摘　　要：目的探讨炎性因子在童年期创伤与抑郁严重程度之间是否存在中介效应。方法纳入92例抑郁症患者,48名健康对照者。根据童年期创伤问卷评估结果,将抑郁症患者分为创伤组(n=50)和无创伤组(n=42)。采用多因子蛋白检测(Luminex)平台检测受试者血浆中白介素(interleukin,IL)-1β、IL-6、IL-8、IL-10和IL-18水平。结果三组比较,IL-1β、IL-6、IL-8和IL-18水平无统计学差异(P>0.05)。创伤组的IL-10水平[1.60(0.29,2.39)pg/mL]与对照组[0.10(0.04,0.42)pg/mL]差异具有统计学意义(P<0.05)。中介效应分析结果显示,童年期创伤与抑郁严重程度存在正关联(β=0.423,R^(2)=0.187,P<0.001),与IL-10存在负关联(β=-0.226,R^(2)=0.048,P=0.003),IL-10在童年期创伤和抑郁严重程度间起部分中介作用(β=0.044,R^(2)=0.217,P<0.001),中介效应占总效应的10.40%。结论IL-10在童年期创伤与抑郁严重程度之间起部分中介作用,童年期创伤可直接影响抑郁情绪的严重程度,也可能通过降低IL-10水平间接影响抑郁情绪。Objective To investigate whether inflammatory factors mediate the relationship between childhood trauma and depression severity.Methods A total of 92 patients with depression and 48 healthy controls were enrolled.According to the evaluation results of childhood trauma questionnaire,depression patients were divided into trauma group(n=50)and non-trauma group(n=42).Plasma levels of interleukin-1beta(IL-1β),interleukin-6(IL-6),interleukin-8(IL-8),interleukin-10(IL-10)and interleukin-18(IL-18)were determined by Luminex platform.Non-parametric test,chi-square test,Pearson correlation analysis and mediating effect test were used for data analysis.Results There were no significant differences in the levels of IL-1β,IL-6,IL-8 and IL-18 among the three groups(P>0.05).Compared with the healthy control group,the level of IL-10 in the trauma group[1.60(0.29,2.39)pg/mL vs.0.10(0.04,0.42)pg/mL]was significantly different(P<0.05).The results of mediating analysis showed that childhood trauma was positively correlated with depression severity(β=0.423,R^(2)=0.187,P<0.001)while negatively correlated with IL-10(β=-0.226,R^(2)=0.048,P=0.003).IL-10 partially mediated the relationship between childhood trauma and depression severity(β=0.044,R^(2)=0.217,P<0.001),and the mediating effect accounted for 10.40%of the total effect.Conclusions IL-10 partially mediates the relationship between childhood trauma and depression severity.Childhood trauma can directly affect the severity of depressive mood and may also affect depressive mood indirectly by lowering IL-10 levels.

关 键 词：童年期创伤 抑郁症 白介素10 白介素1Β 白介素6 白介素8 白介素18 中介效应 

分 类 号：R749.4[医药卫生—神经病学与精神病学]