功能性食品及药食同源产品中抗抑郁活性成分及其作用机制  

Antidepressant-like active ingredients and their related mechanisms of functional foods or medicine and food homologous products

作　　者：叶恬 徐梦涛 方景鹏 吴沁璇 邹小艳 颜昉芩 卿志星 YE Tian;XU Mengtao;FANG Jingpeng;WU Qinxuan;ZOU Xiaoyan;YAN Fangqin;QING Zhixing(Hunan Key Laboratory of Traditional Chinese Veterinary Medicine,Hunan Agricultural University,Changsha,Hunan 410128,China;College of Pharmacy,Changsha Medical University,Changsha,Hunan 410219,China;College of Chemistry,Zhengzhou University,Zhengzhou,Henan 450001,China)

机构地区：[1]湖南农业大学中兽药湖南省重点实验室,湖南长沙410128 [2]长沙医学院药学系,湖南长沙410219 [3]郑州大学化学学院,河南郑州450001

出　　处：《Digital Chinese Medicine》2023年第1期9-27,共19页数字中医药（英文）

基　　金：National Key Rearch and Development Program of China(2021YFD1600301);Scientific Research Cooperation Project of Datong Daylily Industial Development Research Institute(2022QT003-3);Hunan Provincial Natural Science Foundation of China(2021JJ40245);Hong Kong Scholars Program(2021-164);Hunan Provincial Key Research and Development Project(2020NK2031)。

摘　　要：目的本研究通过总结归纳功能性食品及药食同源产品中活性成分的抗抑郁作用及其机制,以期为抑郁症的治疗提供一种新思路。方法通过PubMed,谷歌学术,Web of Science及中国知网数据库收集与功能性食品或食品同源产品抗抑郁相关的文献,检索时限为1996年9月25日至2022年9月5日,系统总结与分析其抗抑郁活性成分及作用机制。结果研究最终纳入文献146篇,共计67种植物来源的功能性食品或药食同源产品、32种具有抗抑郁活性的提取物(含8种黄酮提取物)和87种抗抑郁活性成分。87种抗抑郁活性成份包括萜类7种,皂苷类22种,黄酮类15种,苯丙素类11种,酚类7种,糖类6种,生物碱类8种,其他类11种。结论本综述对功能性食品及药食同源产品中抗抑郁活性成分及作用机制进行总结与分析,为新型抗抑郁药物的开发提供了新的视野,同时也为抑郁症患者的治疗提供一种潜在替代治疗方案。Objective To provide a new idea for the treatment of depression by summarizing the antidepressant effect and mechanism of active ingredients in functional food,and medicine and food homologous products.Methods The literature related to the antidepressant of functional food or medicine and food homologous products from September 25,1996 to September 5,2022 was collected through PubMed,Google Academic,Web of Science,and China National Knowledge Infrastructure(CNKI)databases.After that,their antidepressant active ingredients and mechanism of action were systematically summarized and analyzed.Results A total of 146 pieces of literature were involved in the study,including 67 plant-derived functional foods or medicine and food homologous products,32 antidepressant extracts(including 8 flavonoid extracts),and 87 antidepressant active ingredients.The 87 antidepressant active ingredients include 7 terpenes,22 saponins,15 flavonoids,11 phenylpropanoids,7 phenols,6 sugars,8 alkaloids,and 11 others.Conclusion The study summarized and analyzed the active ingredients and mechanisms of antidepressants in functional foods and medicine and food homologous products,which provides a new vision for the development of new antidepressants and a potential alternative treatment for patients with depression.

关 键 词：抗抑郁 药食同源 功能性食品 提取物 活性成分 中医药 

分 类 号：TS218[轻工技术与工程—粮食、油脂及植物蛋白工程]