血清神经元特异性烯醇化酶、胃泌素释放肽前体、组织多肽抗原检测对非小细胞肺癌的诊断价值  

Diagnostic value of serum neuron specific enolase,pro-gastrin-releasing peptide and tissue peptide antigen in non-small cell lung cancer

作　　者：赵迁楠 崔翠莲 ZHAO Qiannan;CUI Cuilian(Department of Clinical Laboratory,Emergency General Hospital,Beijing 100028,China)

机构地区：[1]应急总医院检验科,北京100028

出　　处：《癌症进展》2023年第6期649-651,共3页Oncology Progress

摘　　要：目的探讨血清神经元特异性烯醇化酶(NSE)、组织多肽抗原(TPA)、胃泌素释放肽前体(ProGRP)检测对非小细胞肺癌的诊断价值。方法选取80例非小细胞肺癌患者作为肺癌组,另选取80例肺良性疾病患者作为对照组。比较两组患者血清NSE、ProGRP、TPA水平,比较血清NSE、ProGRP、TPA单独及联合检测对非小细胞肺癌的诊断效能。结果肺癌组患者血清NSE、ProGRP、TPA水平均明显高于对照组,差异均有统计学意义(P﹤0.01)。血清NSE、ProGRP、TPA联合检测诊断非小细胞肺癌的灵敏度、阳性预测值、阴性预测值、约登指数分别为88.75%、79.78%、87.32%、0.662,均高于血清NSE、ProGRP、TPA单独检测。结论血清NSE、ProGRP、TPA联合检测可提高非小细胞肺癌的诊断效能。Objective To evaluate the diagnostic value of serum neuron specific enolase(NSE),tissue peptide antigen(TPA)and pro-gastrin-releasing peptide(ProGRP)in non-small cell lung cancer.Method A total of 80 patients with non-small cell lung cancer were selected as lung cancer group,and another 80 patients with benign lung disease were selected as control group.The serum levels of NSE,ProGRP and TPA were compared between the two groups,and the diagnostic efficacy of serum NSE,ProGRP and TPA alone and in combination determination in non-small cell lung cancer were compared.Result The levels of serum NSE,ProGRP and TPA in lung cancer group were higher than those in control group,and the differences were statistically significant(P<0.01).The sensitivity,positive predictive value,negative predictive value and Yoden index of the combined determination of serum NSE,ProGRP and TPA in the diagnosis of nonsmall cell lung cancer were 88.75%,79.78%,87.32%and 0.662,respectively,which were higher than those of serum NSE,ProGRP and TPA alone.Conclusion The combined determination of serum NSE,ProGRP and TPA can improve the diagnostic efficiency of non-small cell lung cancer.

关 键 词：非小细胞肺癌 神经元特异性烯醇化酶 组织多肽抗原 胃泌素释放肽前体 诊断价值 

分 类 号：R734.2[医药卫生—肿瘤]