急性颈内动脉系统脑梗死患者静脉溶栓预后及影响因素分析  

Prognosis and influencing factors of patients with acute cerebral infarction of internal carotid artery system after intravenous thrombolysis

作　　者：张笑 ZHANG Xiao(Department of Neurology of Zhecheng Hospital of Traditional Chinese Medicine,Shangqiu 476200 Henan,China)

机构地区：[1]柘城中医院神经内科,河南商丘476200

出　　处：《中国民康医学》2023年第7期20-22,32,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:分析急性颈内动脉系统脑梗死患者静脉溶栓预后情况及影响因素。方法:选取2019年10月至2021年4月该院139例急性颈内动脉系统脑梗死患者进行前瞻性研究,均行静脉溶栓治疗,统计患者预后情况,将其分为预后良好组(n=65)和预后不良组(n=74),比较两组基线资料,并分析急性颈内动脉系统脑梗死患者静脉溶栓后预后不良的影响因素。结果:139例急性颈内动脉系统脑梗死患者静脉溶栓治疗后,预后良好65例,占46.76%,预后不良74例,占53.24%;预后不良组合并房颤、发病至溶栓时间≥3 h、合并糖尿病、病情中重度占比均高于对照组,差异有统计学意义(P<0.05);两组性别、年龄、饮酒史、吸烟史、合并高血压、入院时低密度脂蛋白胆固醇≤3.1 mmol/L占比比较,差异均无统计学意义(P>0.05);Logistic回归分析显示,合并房颤、发病至溶栓时间≥3 h、合并糖尿病、病情中重度均为影响急性颈内动脉系统脑梗死患者静脉溶栓后预后不良的危险因素。结论:合并房颤、发病至溶栓时间≥3 h、合并糖尿病、病情中重度均为影响急性颈内动脉系统脑梗死患者静脉溶栓后预后不良的危险因素。Objective:To analyze prognosis and influencing factors of patients with acute cerebral infarction of internal carotid artery system after intravenous thrombolysis.Methods:A prospective study was conducted on 139 patients with acute cerebral infarction of the internal carotid artery system in the hospital from October 2019 to April 2021,all of whom received thrombolytic therapy.The prognosis of these patients was statistically analyzed.These patients were divided into good prognosis group(n=65)and poor prognosis group(n=74)based on the modified Rankin scale score(mRS)and Barthel index(BI)score after 90 days of treatment.The baseline data of the two groups were analyzed.Further,the influencing factors of poor prognosis after intravenous thrombolysis in the patients with acute cerebral infarction of internal carotid artery system were analyzed.Results:After the intravenous thrombolysis therapy of the 139 patients with acute cerebral infarction of internal carotid artery system,the prognosis was good in 65 cases(46.76%)and poor in 74 cases(53.24%).The proportions of combined atrial fibrillation,the interval between onset and thrombolysis≥3 h,combined diabetes,and moderate and severe condition in the poor prognosis group were higher than good prognosis group,and the differences were statistically significant(P<0.05).There were no statistically significant differences in gender,age,history of alcohol consumption,smoking history,combined hypertension,and the proportion of LDL-C≤3.1 mmol/L at admission between the two groups(P>0.05).Logistic regression analysis showed that combined atrial fibrillation,the interval between onset and thrombolysis≥3 h,combined diabetes,and moderate to severe condition were risk factors for poor prognosis of the patients with acute cerebral infarction of internal carotid artery system after intravenous thrombolysis.Conclusions:Combined atrial fibrillation,the interval between onset and thrombolysis≥3 h,combined diabetes,and moderate to severe condition are the risk factors for poor p

关 键 词：急性颈内动脉系统脑梗死 静脉溶栓 预后不良 影响因素 

分 类 号：R743.3[医药卫生—神经病学与精神病学]