P2嘌呤受体在神经病理性疼痛中的作用:文献综述  

Research progresses of P2 purine receptor in neuropathic pain: a literature review

作　　者：罗想 周琪[1] 宋健楠[1] 李海波[1] 毕立伟 Luo Xiang;Zhou Qi;Song Jiannan;Li Haibo;Bi Liwei(Department of Anesthesiology,Chifeng Municipal Hospital,Chifeng City,Inner Mongolia Autonomous Region 024000,China)

机构地区：[1]内蒙古自治区赤峰市医院麻醉科,赤峰市024000

出　　处：《中华疼痛学杂志》2023年第1期146-152,共7页Chinese Journal Of Painology

摘　　要：P2嘌呤受体广泛参与神经病理性疼痛的产生和调节, 对周围和中枢神经系统的多个部位细胞间通讯的调节也起着关键的作用, 提示它可能在疼痛防治方面扮演重要角色。P2嘌呤受体分为离子通道型(P2X)受体和G蛋白偶联型(P2Y)受体, P2嘌呤受体参与机体组织器官多种功能的调节, 同时在痛觉信号传递过程中发挥重要作用。本文综述P2嘌呤受体与神经病理性疼痛的关系及其在治疗中的潜在作用。The P2 purine receptors are widely involved in the generation and regulation of neuropathic pain,and play an important role in the regulation of intercellular communication in multiple parts of the peripheral and central nervous system,indicating their important role in the treatment of pain.P2 purine receptors are mainly divided into ion channel P2X receptors and G-protein coupling P2Y receptors,participate in the regulation of various functions of tissues and organs,and play an important role in the process of pain signal transmission.This paper reviews the relationship between P2 purine receptors and neuropathic pain and its potential target in treatment of neuropathic pain.

关 键 词：神经痛 P2X受体 P2Y受体 神经损伤 

分 类 号：R741[医药卫生—神经病学与精神病学]