维甲酸在脑缺血及卒中后抑郁中的作用  

The role of retinoic acid in cerebral ischemia and post-stroke depression

作　　者：尚文豆 鲁娇 储晓娇 何治[1,2] SHANG Wen-Dou;LU Jiao;CHU Xiao-Jiao;He Zhi(Third-grade Pharmacological Laboratory on Traditional Chinese Medicine,State Administration of Traditional Chinese Medicine,China Three Gorges University,Yichang 443002,China;Medical College,China Three Gorges University,Yichang 443002,China)

机构地区：[1]三峡大学国家中医药管理局中药药理科研三级实验室,宜昌443002 [2]三峡大学医学院,宜昌443002

出　　处：《生命科学》2023年第3期378-386,共9页Chinese Bulletin of Life Sciences

基　　金：天然产物研究与利用湖北省重点实验室开放基金(NPRD-2018001);湖北省卫健委联合基金重点项目(WJ2019H526);国家自然科学基金面上项目(82073824)。

摘　　要：脑缺血及缺血后再灌注过程的病理生理机制复杂,发病后可能伴随卒中后抑郁等精神障碍,对人类生命和生活质量产生很大的威胁。目前的溶栓和取栓治疗具有极大限制性,寻求一种理想的神经保护药物对于治疗脑缺血有极其重要的临床意义。近年研究发现维甲酸不仅可通过调节炎症反应、保护血脑屏障、抗凋亡、促进神经再生等过程对脑缺血性疾病发挥保护作用,并且血清维甲酸水平在脑缺血及卒中后抑郁中可作为一项独立的指标发挥预测作用。该文将针对维甲酸在脑缺血及卒中后抑郁中的作用进行综述。The pathophysiological mechanism of cerebral ischemia and post-ischemic reperfusion process is complex,and it may be accompanied by mental disorders such as post-stroke depression after the onset,which poses a great threat to human life.Current thrombolysis and thrombectomy treatments are extremely restrictive,and the search for an ideal neuroprotective drug is of great clinical significance for the treatment of cerebral ischemia.Recent studies have found that retinoic acid can not only play a protective role against cerebral ischemic diseases by regulating inflammatory response,protecting the blood-brain barrier,anti-apoptosis,and promoting nerve regeneration,but also serum retinoic acid levels can play an independent predictive role in cerebral ischemia and post-stroke depression.This article will review the role of retinoic acid in cerebral ischemia and post-stroke depression.

关 键 词：维甲酸 视黄酸 脑缺血 神经保护 卒中后抑郁 

分 类 号：R743.3[医药卫生—神经病学与精神病学] R749.4[医药卫生—临床医学] R96