PIEZO1 channels in cutaneous free nerve endings:novel insights into itch-scratch-mechanisms  

作　　者：Manuel Pedro Pereira Henning Wiegmann Sonja Ständer 

机构地区：[1]Department of Dermatology and Center for Chronic Pruritus,University Hospital Münster,48149,Münster,Germany

出　　处：《Signal Transduction and Targeted Therapy》2023年第2期319-320,共2页信号转导与靶向治疗（英文）

基　　金：Open Access funding enabled and organized by Projekt DEAL.

摘　　要：A recent study published in Nature by Hill et al.1 identified mechano-sensitive PIEZO1 ion channels in pruriceptive neurons.Remarkably,PIEZO1 is involved in acute itch transmission and in mechanical alloknesis in chronic pruritus(CP)states.Itch is defined as an unpleasant sensation leading to the desire to scratch.

关 键 词：ZO1 INSIGHT SCRATCH 

分 类 号：R758.31[医药卫生—皮肤病学与性病学]