Neoantigens:promising targets for cancer therapy  

作　　者：Na Xie Guobo Shen Wei Gao Zhao Huang Canhua Huang Li Fu 

机构地区：[1]State Key Laboratory of Biotherapy and Cancer Center,West China Hospital,and West China School of Basic Medical Sciences and Forensic Medicine,Sichuan University,and Collaborative Innovation Center for Biotherapy,Chengdu,610041,China [2]Clinical Genetics Laboratory,Affiliated Hospital&Clinical Medical College of Chengdu University,Chengdu,610081,China [3]Guangdong Provincial Key Laboratory of Regional Immunity and Diseases,Department of Pharmacology and International Cancer Center,Shenzhen University Health Science Center,Shenzhen,518060,Guangdong,People’s Republic of China

出　　处：《Signal Transduction and Targeted Therapy》2023年第2期446-483,共38页信号转导与靶向治疗（英文）

基　　金：This work was supported by grants from the National Key R&D Program of China(2020YFA0509400);Guangdong Basic and Applied Basic Research Foundation(2019B030302012);the National Natural Science Foundation of China(81821002,82130082,81790251,81972665,82173003,82102738 and 82103168);1·3·5 project for disciplines of excellence,West China Hospital,Sichuan University(ZYGD22007 and ZYJC21004);the Science and Technology Foundation of Shenzhen(JCYJ20200109113810154).BioRender was used to create the figures.

摘　　要：Recent advances in neoantigen research have accelerated the development and regulatory approval of tumor immunotherapies,including cancer vaccines,adoptive cell therapy and antibody-based therapies,especially for solid tumors.Neoantigens are newly formed antigens generated by tumor cells as a result of various tumor-specific alterations,such as genomic mutation,dysregulated RNA splicing,disordered post-translational modification,and integrated viral open reading frames.Neoantigens are recognized as non-self and trigger an immune response that is not subject to central and peripheral tolerance.The quick identification and prediction of tumor-specific neoantigens have been made possible by the advanced development of next-generation sequencing and bioinformatic technologies.Compared to tumor-associated antigens,the highly immunogenic and tumor-specific neoantigens provide emerging targets for personalized cancer immunotherapies,and serve as prospective predictors for tumor survival prognosis and immune checkpoint blockade responses.The development of cancer therapies will be aided by understanding the mechanism underlying neoantigen-induced anti-tumor immune response and by streamlining the process of neoantigen-based immunotherapies.This review provides an overview on the identification and characterization of neoantigens and outlines the clinical applications of prospective immunotherapeutic strategies based on neoantigens.We also explore their current status,inherent challenges,and clinical translation potential.

关 键 词：ANTIGENS alterations APPROVAL 

分 类 号：R730.5[医药卫生—肿瘤]