Dehydroepiandrosterone sulfate supplementation in health and diseases  

作　　者：Parth Jethwani Ashu Rastogi Ravindra Shukla 

机构地区：[1]Department of Endocrinology&Metabolism,All India Institute of Medical Sciences Jodhpur,Jodhpur 342001,Rajasthan,India [2]Department of Endocrinology,Postgraduate Institution of Medical education and Research Chandigarh,Chandigarh 160017,Chandigarh,India

出　　处：《World Journal of Meta-Analysis》2023年第4期102-111,共10页世界荟萃分析杂志

摘　　要：Dehydroepiandrosterone sulfate(DHEAS)is a hormone produced by the zona reticularis of the adrenal gland and the ovaries.Initially considered as an inert compound merely serving as an intermediate in the conversion of cholesterol to androgens,interest in DHEA began to grow in the 1960s when it was found that DHEAS is the most abundant steroid hormone in human plasma and that its levels decline with age.In many countries,DHEA is considered a nutritional supplement.It has been used for a multitude of conditions which include sexual dysfunction,infertility,genitourinary syndrome of menopause,musculoskeletal disorders,cardiovascular diseases,ageing,neurological diseases,autoimmune conditions,adrenal insufficiency,and anorexia nervosa.We describe an overview of the historical evolution of DHEA,its physiology,and the disease states where it has been evaluated as a supplement.

关 键 词：DEHYDROEPIANDROSTERONE ADRENAL Health supplements HYPOTHYROIDISM AUTOIMMUNITY DEPRESSION Cardiovascular disease 

分 类 号：R71[医药卫生—妇产科学]