Short-term outcome of total knee replacement in a patient with hemophilia:A case report and review of literature  

作　　者：De-Long Yin Jia-Min Lin Yuan-Hui Li Peng Chen Mian-Dong Zeng 

机构地区：[1]Department of Orthopedic,The Third Affiliated Hospital of Guangzhou Medical University,Guangzhou 510150,Guangdong Province,China [2]Department of Orthopedic,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,Hubei Province,China [3]Department of Orthopedic,Yichang Chinese Medicine Hospital,Yichang 443003,Hubei Province,China

出　　处：《World Journal of Clinical Cases》2023年第12期2788-2795,共8页世界临床病例杂志

摘　　要：BACKGROUND Hemophilia A is a rare inherited bleeding disorder caused by mutations in the factor Ⅷ gene. This clotting factor plays an intrinsic role in the blood coagulation pathway. Patients with hemophilia may develop orthopedic manifestations such as hemarthrosis, but multiple malunion of fractures over the knee is rare and difficult to treat.CASE SUMMARY We report a patient with hemophilia A who developed severe knee osteoarthritis along with fracture malunion and nonunion. Total knee replacement was performed using a custom-made modular hinged knee prosthesis(cemented) equipped with extended distal and proximal stems. At 3 years’ follow-up, the patient exhibited excellent clinical function and remained satisfied with the surgical outcome. Surgical intervention was accompanied by rigorous coagulation factor replacement.CONCLUSION This case highlights various unique scenarios specific to individuals with hemophilia and fracture deformity.

关 键 词：Total knee replacement HEMOPHILIA Multiple malunion of fractures Hemophiliac arthropathy Coagulation factor replacement Case report 

分 类 号：R687.4[医药卫生—骨科学] R554.1[医药卫生—外科学]