supported by Pfizer and the Haemophilia,Experience,Results,and Opportunities(HERO)Research Grant(Novo Nordisk).
Objective:Hemophilia carriers(HCs),who are heterozygous for mutations in the clotting factor VIII/clotting factor IX gene(F8 or F9),may have a wide range of clotting factor levels,from very low,similar to afflicted ma...
supported by the CAMS Innovation Fund for Medical Sciences(CIFMS)(No.2021-I2M-1-003).
Hemophilia is a hemorrhagic disease caused by a lack of clotting factors due to genetic mutations,and is a representative of rare diseases.The prevalence rate of hemophilia is about 2.73/100,000–3.09/100,000 in China...
Introduction and objective: Hemophilia is a genetic bleeding disorder inherited as a recessive train linked to the male gender. Bleeding into the central nervous system in patients with hemophilia is an extremely dang...
BACKGROUND Hemophilia A is a rare inherited bleeding disorder caused by mutations in the factor Ⅷ gene. This clotting factor plays an intrinsic role in the blood coagulation pathway. Patients with hemophilia may deve...
supported by grants from the National Natural Science Foundation of China(No.81300383);the Clinical Research Center of Shandong University(No.2020SDUCRCC015);Young Taishan Scholar Foundation of Shandong Province(No.tsqn202103167).
Gene therapy refers to introducing normal exogenous genes into target cells to correct or compensate for the diseases caused by defective and abnormal genes for the purpose of therapy.It holds out hope of a cure for s...
Dental practitioners must be well informed about the pathology, complications and treatment options associated with bleeding disorders patients. Prolongation of bleeding time can seriously complicate the patient’s co...
Numerous studies are being carried out on polymorphisms within the genes coding for factors VIII and IX due to their clinical relevance in the context of hereditary disorders. The quests for polymorphism can be used t...
Supported by the Foundation of Science and Technology Department of Zhejiang Province,No.LGF19H060010;the Foundation of Health and Family Planning Commission of Zhejiang Province,No.2021KY445.
BACKGROUND Various tumors and tumor-like disorders,originating from the neural sheath,as well as other types,may affect the brachial plexus region.Due to the infrequent presentation,brachial plexus palsy caused by spo...
The study was financially supported by the Project of New Technology and New Business of Nanfang Hospital,Southern Medical University(No.2016018).
Objective Contrast-enhanced ultrasound(CEUS)is advantageous for evaluating microcirculation,and has been applied to assess arthritis in previous studies.However,CEUS examinations have not been studied for hemophilia a...